CNOT7

CNOT7 (CCR4-NOT Transcription Complex Subunit 7) is a Protein Coding gene. Among its related pathways are Cyclins and Cell Cycle Regulation and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is CNOT8.

Full Name

CCR4-NOT Transcription Complex Subunit 7

Function

Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.

Biological Process

Deadenylation-dependent decapping of nuclear-transcribed mRNA Source: Ensembl
Defense response to virus Source: UniProtKB
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
Exonucleolytic catabolism of deadenylated mRNA Source: UniProtKB
Gene silencing by miRNA Source: UniProtKB
Gene silencing by RNA Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of gene expression Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of translation Source: GO_Central
Negative regulation of type I interferon-mediated signaling pathway Source: UniProtKB
Nuclear-transcribed mRNA poly(A) tail shortening Source: Reactome
P-body assembly Source: Ensembl
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of mRNA catabolic process Source: UniProtKB
Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: UniProtKB
Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of viral genome replication Source: UniProtKB
Regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB

Cellular Location

Nucleus; P-body. NANOS2 promotes its localization to P-body.