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Mouse Anti-CNPY2 Recombinant Antibody (448) (CBMAB-AP1605LY)


See all CNPY2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
448
Antibody Isotype
IgG2b
Application
ELISA, IF, IHC, WB

Basic Information

Immunogen
Fusion protein of CNPY2/ MSAP
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Canopy FGF Signaling Regulator 2
Introduction
CNPY2 (Canopy FGF Signaling Regulator 2) is a Protein Coding gene. An important paralog of this gene is ENSG00000144785.
Entrez Gene ID
Human10330
Mouse56530
Rat685814
UniProt ID
HumanQ9Y2B0
MouseQ9QXT0
RatA0JN30
Alternative Names
Canopy FGF Signaling Regulator 2; Transmembrane Protein 4; MIR-Interacting Saposin-Like Protein; Putative Secreted Protein Zsig9; TMEM4; ZSIG9;
Function
Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation.
Biological Process
Negative regulation of gene expression Source: BHF-UCL
Positive regulation of low-density lipoprotein receptor activity Source: BHF-UCL
Regulation of low-density lipoprotein particle clearance Source: BHF-UCL
Cellular Location
Endoplasmic reticulum

Gao, K., Wang, T., Qiao, Y., & Cui, B. (2021). MicroRNA-30e-3p inhibits glioma development and promotes drug sensitivity to temozolomide treatment via targeting canopy FGF signaling regulator 2. Cell Cycle, 20(22), 2361-2371.

Zhao, L., Li, H., Gao, Q., Xu, J., Zhu, Y., Zhai, M., ... & Liu, C. (2021). Berberine Attenuates Cerebral Ischemia-Reperfusion Injury Induced Neuronal Apoptosis by Down-Regulating the CNPY2 Signaling Pathway. Frontiers in pharmacology, 12.

Lo, L. H., Lam, C. Y., To, J. C., Chiu, C. H., & Keng, V. W. (2021). Sleeping Beauty insertional mutagenesis screen identifies the pro-metastatic roles of CNPY2 and ACTN2 in hepatocellular carcinoma tumor progression. Biochemical and Biophysical Research Communications, 541, 70-77.

Liu, C., Liu, Y., He, J., Mu, R., Di, Y., Shen, N., ... & Tian, F. (2019). Liraglutide increases VEGF expression via CNPY2-PERK pathway induced by hypoxia/reoxygenation injury. Frontiers in Pharmacology, 10, 789.

Ito, S., Ueno, A., Ueda, T., Nakagawa, H., Taniguchi, H., Kayukawa, N., ... & Ukimura, O. (2018). CNPY2 inhibits MYLIP-mediated AR protein degradation in prostate cancer cells. Oncotarget, 9(25), 17645.

Yu, D., Qin, Y., Jun-Qiang, L., & Shun-Lin, G. (2018). CNPY2 enhances resistance to apoptosis induced by cisplatin via activation of NF-κB pathway in human non-small cell lung cancer. Biomedicine & Pharmacotherapy, 103, 1658-1663.

Taniguchi, H., Ito, S., Ueda, T., Morioka, Y., Kayukawa, N., Ueno, A., ... & Ukimura, O. (2017). CNPY2 promoted the proliferation of renal cell carcinoma cells and increased the expression of TP53. Biochemical and biophysical research communications, 485(2), 267-271.

Hong, F., Liu, B., Wu, B. X., Morreall, J., Roth, B., Davies, C., ... & Li, Z. (2017). CNPY2 is a key initiator of the PERK–CHOP pathway of the unfolded protein response. Nature structural & molecular biology, 24(10), 834-839.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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