Mouse Anti-CNPY2 Recombinant Antibody (CBWJC-2878) (CBMAB-C4004WJ)

Name: Mouse Anti-CNPY2 Recombinant Antibody (CBWJC-2878)
SKU: CBMAB-C4004WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJC-2878

Application

WB, IF, IHC-P, FC

Immunogen

CNPY2, MSAP Fusion Protein (1-182 aa).

Host Species

Mouse

Specificity

Human, Mouse, Rat, Pig

Antibody Isotype

IgG2b

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
FC	0.2 µg/10^6 cells
WB	1:500-1:2,000
IHC	1:50-1:500
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Canopy FGF Signaling Regulator 2

Introduction

CNPY2 (Canopy FGF Signaling Regulator 2) is a Protein Coding gene. An important paralog of this gene is ENSG00000144785.

Entrez Gene ID

Human	10330
Mouse	56530
Rat	685814

UniProt ID

Human	Q9Y2B0
Mouse	Q9QXT0
Rat	A0JN30

Alternative Names

Canopy FGF Signaling Regulator 2; Transmembrane Protein 4; MIR-Interacting Saposin-Like Protein; Putative Secreted Protein Zsig9; TMEM4; ZSIG9;

Function

Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation.

Biological Process

Negative regulation of gene expression Source: BHF-UCL
Positive regulation of low-density lipoprotein receptor activity Source: BHF-UCL
Regulation of low-density lipoprotein particle clearance Source: BHF-UCL

Cellular Location

Endoplasmic reticulum

Gao, K., Wang, T., Qiao, Y., & Cui, B. (2021). MicroRNA-30e-3p inhibits glioma development and promotes drug sensitivity to temozolomide treatment via targeting canopy FGF signaling regulator 2. Cell Cycle, 20(22), 2361-2371.

Zhao, L., Li, H., Gao, Q., Xu, J., Zhu, Y., Zhai, M., ... & Liu, C. (2021). Berberine Attenuates Cerebral Ischemia-Reperfusion Injury Induced Neuronal Apoptosis by Down-Regulating the CNPY2 Signaling Pathway. Frontiers in pharmacology, 12.

Lo, L. H., Lam, C. Y., To, J. C., Chiu, C. H., & Keng, V. W. (2021). Sleeping Beauty insertional mutagenesis screen identifies the pro-metastatic roles of CNPY2 and ACTN2 in hepatocellular carcinoma tumor progression. Biochemical and Biophysical Research Communications, 541, 70-77.

Liu, C., Liu, Y., He, J., Mu, R., Di, Y., Shen, N., ... & Tian, F. (2019). Liraglutide increases VEGF expression via CNPY2-PERK pathway induced by hypoxia/reoxygenation injury. Frontiers in Pharmacology, 10, 789.

Ito, S., Ueno, A., Ueda, T., Nakagawa, H., Taniguchi, H., Kayukawa, N., ... & Ukimura, O. (2018). CNPY2 inhibits MYLIP-mediated AR protein degradation in prostate cancer cells. Oncotarget, 9(25), 17645.

Yu, D., Qin, Y., Jun-Qiang, L., & Shun-Lin, G. (2018). CNPY2 enhances resistance to apoptosis induced by cisplatin via activation of NF-κB pathway in human non-small cell lung cancer. Biomedicine & Pharmacotherapy, 103, 1658-1663.

Taniguchi, H., Ito, S., Ueda, T., Morioka, Y., Kayukawa, N., Ueno, A., ... & Ukimura, O. (2017). CNPY2 promoted the proliferation of renal cell carcinoma cells and increased the expression of TP53. Biochemical and biophysical research communications, 485(2), 267-271.

Hong, F., Liu, B., Wu, B. X., Morreall, J., Roth, B., Davies, C., ... & Li, Z. (2017). CNPY2 is a key initiator of the PERK–CHOP pathway of the unfolded protein response. Nature structural & molecular biology, 24(10), 834-839.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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