Mouse Anti-CNPY2 Recombinant Antibody (CBXC-2698) (V2LY-1206-LY494)

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Basic Information

Host Animal
Mouse
Clone
CBXC-2698
Application
ELISA, WB
Immunogen
Canopy 2 homolog (zebrafish).
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Canopy FGF Signaling Regulator 2
Entrez Gene ID
UniProt ID
Function
Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation.
Biological Process
Negative regulation of gene expression Source: BHF-UCL
Positive regulation of low-density lipoprotein receptor activity Source: BHF-UCL
Regulation of low-density lipoprotein particle clearance Source: BHF-UCL
Cellular Location
Endoplasmic reticulum

Gao, K., Wang, T., Qiao, Y., & Cui, B. (2021). MicroRNA-30e-3p inhibits glioma development and promotes drug sensitivity to temozolomide treatment via targeting canopy FGF signaling regulator 2. Cell Cycle, 20(22), 2361-2371.

Zhao, L., Li, H., Gao, Q., Xu, J., Zhu, Y., Zhai, M., ... & Liu, C. (2021). Berberine Attenuates Cerebral Ischemia-Reperfusion Injury Induced Neuronal Apoptosis by Down-Regulating the CNPY2 Signaling Pathway. Frontiers in pharmacology, 12.

Lo, L. H., Lam, C. Y., To, J. C., Chiu, C. H., & Keng, V. W. (2021). Sleeping Beauty insertional mutagenesis screen identifies the pro-metastatic roles of CNPY2 and ACTN2 in hepatocellular carcinoma tumor progression. Biochemical and Biophysical Research Communications, 541, 70-77.

Liu, C., Liu, Y., He, J., Mu, R., Di, Y., Shen, N., ... & Tian, F. (2019). Liraglutide increases VEGF expression via CNPY2-PERK pathway induced by hypoxia/reoxygenation injury. Frontiers in Pharmacology, 10, 789.

Ito, S., Ueno, A., Ueda, T., Nakagawa, H., Taniguchi, H., Kayukawa, N., ... & Ukimura, O. (2018). CNPY2 inhibits MYLIP-mediated AR protein degradation in prostate cancer cells. Oncotarget, 9(25), 17645.

Yu, D., Qin, Y., Jun-Qiang, L., & Shun-Lin, G. (2018). CNPY2 enhances resistance to apoptosis induced by cisplatin via activation of NF-κB pathway in human non-small cell lung cancer. Biomedicine & Pharmacotherapy, 103, 1658-1663.

Taniguchi, H., Ito, S., Ueda, T., Morioka, Y., Kayukawa, N., Ueno, A., ... & Ukimura, O. (2017). CNPY2 promoted the proliferation of renal cell carcinoma cells and increased the expression of TP53. Biochemical and biophysical research communications, 485(2), 267-271.

Hong, F., Liu, B., Wu, B. X., Morreall, J., Roth, B., Davies, C., ... & Li, Z. (2017). CNPY2 is a key initiator of the PERK–CHOP pathway of the unfolded protein response. Nature structural & molecular biology, 24(10), 834-839.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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