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Mouse Anti-COL25A1 (AA 189-654) Recombinant Antibody (CBFYC-2049) (CBMAB-C2115-FY)

This product is mouse antibody that recognizes COL25A1. The antibody CBFYC-2049 can be used for immunoassay techniques such as: ELISA, IHC.
See all COL25A1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-2049
Antibody Isotype
IgG2b
Application
ELISA, IHC

Basic Information

Immunogen
Recombinant corresponding to aa189-654 from human COL25A1 expressed in NSO cells (Q9BXS0)
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 189-654

Target

Full Name
collagen, type XXV, alpha 1
Introduction
COL25A1 (Collagen Type XXV Alpha 1 Chain) is a Protein Coding gene. Diseases associated with COL25A1 include Fibrosis Of Extraocular Muscles, Congenital, 5 and Congenital Ptosis. Among its related pathways are Integrin Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include heparin binding and amyloid-beta binding. An important paralog of this gene is COL9A3.
Entrez Gene ID
84570
UniProt ID
Q9BXS0
Alternative Names
Collagen Type XXV Alpha 1 Chain; Alzheimer Disease Amyloid-Associated Protein; CLAC-P; AMY; Collagen-Like Alzheimer Amyloid Plaque Component; Collagenous Alzheimer Amyloid Plaque Component
Function
Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.
Biological Process
Collagen fibril organization Source: Reactome
Cellular Location
Membrane. After proteolytic cleavage, CLAC is secreted.
Involvement in disease
Fibrosis of extraocular muscles, congenital, 5 (CFEOM5):
An ocular motility disorder characterized by congenital dysinnervation of various cranial nerves to ocular muscles. Clinical features are ophthalmoplegia, anchoring of the eyes in downward gaze, ptosis, and backward tilt of the head.
Topology
Cytoplasmic: 1-33
Helical: 34-54
Extracellular: 55-654
PTM
Undergoes proteolytic cleavage by furin protease to yield the soluble collagen-like Alzheimer amyloid plaque component.
Glycosylated.
Hydroxylated on 11% of proline residues and 49% of lysine residues.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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