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Mouse Anti-COPS2 Recombinant Antibody (4B12) (CBMAB-C1397-LY)

This product is antibody recognizes COPS2. The antibody 4B12 immunoassay techniques such as: ELISA, IF, WB.
See all COPS2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4B12
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
COPS2 (NP_004227, 344 a.a. ~ 443 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: REHIEELLRN IRTQVLIKLI KPYTRIHIPF ISKELNIDVA DVESLLVQCI LDNTIHGRID QVNQLLELDH QKRGGARYTA LDKWTNQLNS LNQAVVSKLA
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
COP9 Signalosome Subunit 2
Introduction
COPS2 (COP9 Signalosome Subunit 2) is a Protein Coding gene. Diseases associated with COPS2 include Xeroderma Pigmentosum, Complementation Group E and Decubitus Ulcer. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include signal transducer activity and transcription corepressor activity.
An important paralog of this gene is PSMD11.
Entrez Gene ID
9318
UniProt ID
P61201
Alternative Names
COP9 Signalosome Subunit 2; Thyroid Receptor-Interacting Protein 15; JAB1-Containing Signalosome Subunit 2; TR-Interacting Protein 15; Signalosome Subunit 2; Alien Homolog; TRIP-15; TRIP15;
Function
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
Biological Process
Inner cell mass cell proliferation Source: Ensembl
Negative regulation of nucleic acid-templated transcription Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Neuron differentiation Source: Ensembl
Nucleotide-excision repair, DNA damage recognition Source: Reactome
Post-translational protein modification Source: Reactome
Protein deneddylation Source: UniProtKB
Protein phosphorylation Source: UniProtKB
Signal transduction Source: UniProtKB
Skeletal muscle cell differentiation Source: Ensembl
Transcription by RNA polymerase II Source: UniProtKB
Transcription-coupled nucleotide-excision repair Source: Reactome
Cellular Location
Cytoplasm; Nucleus
PTM
Phosphorylated by CK2 and PKD kinases.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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