COPS2

COPS2 (COP9 Signalosome Subunit 2) is a Protein Coding gene. Diseases associated with COPS2 include Xeroderma Pigmentosum, Complementation Group E and Decubitus Ulcer. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include signal transducer activity and transcription corepressor activity. An important paralog of this gene is PSMD11.

COP9 Signalosome Subunit 2

Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.

Inner cell mass cell proliferation Source: Ensembl
Negative regulation of nucleic acid-templated transcription Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Neuron differentiation Source: Ensembl
Nucleotide-excision repair, DNA damage recognition Source: Reactome
Post-translational protein modification Source: Reactome
Protein deneddylation Source: UniProtKB
Protein phosphorylation Source: UniProtKB
Signal transduction Source: UniProtKB
Skeletal muscle cell differentiation Source: Ensembl
Transcription by RNA polymerase II Source: UniProtKB
Transcription-coupled nucleotide-excision repair Source: Reactome

Cytoplasm; Nucleus

Phosphorylated by CK2 and PKD kinases.