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Mouse Anti-COQ7 Recombinant Antibody (CBWJC-2961) (CBMAB-C4108WJ)

This product is a Mouse antibody that recognizes COQ7. This antibody CBWJC-2961 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all COQ7 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBWJC-2961
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Coenzyme Q7, Hydroxylase
Introduction
COQ7 (Coenzyme Q7, Hydroxylase) is a Protein Coding gene. Diseases associated with COQ7 include Coenzyme Q10 Deficiency, Primary, 8. Among its related pathways are Ubiquinol biosynthesis and Metabolism.
Entrez Gene ID
Human10229
Mouse12850
Rat25249
UniProt ID
HumanQ99807
MouseP97478
RatQ63619
Alternative Names
Coenzyme Q7, Hydroxylase; Ubiquinone Biosynthesis Monooxygenase COQ7; Timing Protein Clk-1 Homolog; DMQ Hydroxylase; 5-Demethoxyubiquinone Hydroxylase, Mitochondrial; Ubiquinone Biosynthesis Protein COQ7 Homolog; Coenzyme Q Biosynthesis Protein 7 Homolog; Coenzyme Q7 Homolog, Ubiquinone (Yeast); COQ7 Coenzyme Q, 7 Homolog Ubiquinone; Coenzyme Q, 7 (Rat, Yeast) Homolog;
Function
Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.
Biological Process
Determination of adult lifespan Source: GO_Central
Negative regulation of transcription by RNA polymerase II Source: WormBase
Positive regulation of transcription by RNA polymerase II Source: WormBase
Regulation of gene expression Source: GO_Central
Regulation of reactive oxygen species metabolic process Source: WormBase
Ubiquinone biosynthetic process Source: GO_Central
Cellular Location
Mitochondrion inner membrane
Involvement in disease
Coenzyme Q10 deficiency, primary, 8 (COQ10D8):
An autosomal recessive disorder resulting from mitochondrial dysfunction and characterized by decreased levels of coenzyme Q10. Patients manifest neonatal lung hypoplasia, contractures, early infantile hypertension and cardiac hypertrophy, secondary to prenatal kidney dysplasia, with neonatal and infantile renal dysfunction. Clinical features also include progressive peripheral neuropathy, muscular hypotonia and atrophy, and mild psychomotor delay with hearing and visual impairment.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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