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Rabbit Anti-COX15 Recombinant Antibody (EG788) (CBMAB-EN943-LY)

The product is antibody recognizes COX15. The antibody EG788 immunoassay techniques such as: IHC: 1:50~1:100 ELISA: 1:1000.
See all COX15 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG788
Antibody Isotype
IgG
Application
IHC: 1:50~1:100 ELISA: 1:1000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human COX15.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
COX15, Cytochrome C Oxidase Assembly Homolog
Introduction
COX15 (COX15, Cytochrome C Oxidase Assembly Homolog) is a Protein Coding gene. Diseases associated with COX15 include Cardioencephalomyopathy, Fatal Infantile, Due To Cytochrome C Oxidase Deficiency 2 and Leigh Syndrome. Among its related pathways are Metabolism and Porphyrin and chlorophyll metabolism. Gene Ontology (GO) annotations related to this gene include cytochrome-c oxidase activity and oxidoreductase activity, acting on the CH-CH group of donors.
Entrez Gene ID
Human1355
Mouse226139
Rat309391
UniProt ID
HumanQ7KZN9
MouseQ8BJ03
RatD4A414
Alternative Names
COX15, Cytochrome C Oxidase Assembly Homolog; COX15 (Yeast) Homolog, Cytochrome C Oxidase Assembly Protein; COX15 Homolog, Cytochrome C Oxidase Assembly Protein; Cytochrome C Oxidase Assembly Protein COX15 Homolog; Cytochrome C Oxidase Assembly Homolog 15; Cytochrome C Oxidase Subunit 15; EC 3.1.3.5; EC 1.4.4.2; CEMCOX2;
Function
May be involved in the biosynthesis of heme A.
Biological Process
Cellular respiration Source: HGNC-UCL
Heme A biosynthetic process Source: HGNC-UCL
Heme biosynthetic process Source: Reactome
Mitochondrial electron transport, cytochrome c to oxygen Source: HGNC-UCL
Proton transmembrane transport Source: BHF-UCL
Respiratory chain complex IV assembly Source: HGNC-UCL
Respiratory gaseous exchange by respiratory system Source: UniProtKB
Cellular Location
Mitochondrion membrane
Involvement in disease
Mitochondrial complex IV deficiency, nuclear type 6 (MC4DN6):
An autosomal recessive multisystem disorder with variable manifestations. Some patients present in the neonatal period with encephalomyopathic features, whereas others present later in the first year of life with developmental regression. Clinical features include microcephaly, encephalopathy, hypertrophic cardiomyopathy, persistent lactic acidosis, respiratory distress, hypotonia and seizures. Serum lactate is increased, and laboratory studies show decreased mitochondrial complex IV protein and activity levels.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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