Mouse Anti-COX15 Recombinant Antibody (CBYY-C2947) (CBMAB-C4390-YY)

Name: Mouse Anti-COX15 Recombinant Antibody (CBYY-C2947)
SKU: CBMAB-C4390-YY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat, Dog, Cattle, Pig, Horse

Clone

CBYY-C2947

Antibody Isotype

IgM, κ

Application

WB, IP, IF, ELISA, IHC-P

Basic Information

Immunogen

Amino acids 89-116 within an internal region of human COX15.

Host Species

Mouse

Specificity

Human, Mouse, Rat, Dog, Cattle, Pig, Horse

Antibody Isotype

IgM, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000
IHC-P	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.1% gelatin

Preservative

0.09% sodium azide

Concentration

0.2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

COX15, Cytochrome C Oxidase Assembly Homolog

Entrez Gene ID

Human	10063
Mouse	12856
Rat	89786

UniProt ID

Human	Q14061
Mouse	P56394
Rat	Q76MV3

Alternative Names

Chorionic Gonadotropin Beta Subunit 2; Chorionic Gonadotropin, Beta Polypeptide 2;

Function

May be involved in the biosynthesis of heme A.

Biological Process

Cellular respiration Source: HGNC-UCL
Heme A biosynthetic process Source: HGNC-UCL
Heme biosynthetic process Source: Reactome
Mitochondrial electron transport, cytochrome c to oxygen Source: HGNC-UCL
Proton transmembrane transport Source: BHF-UCL
Respiratory chain complex IV assembly Source: HGNC-UCL
Respiratory gaseous exchange by respiratory system Source: UniProtKB

Cellular Location

Mitochondrion membrane

Involvement in disease

Mitochondrial complex IV deficiency, nuclear type 6 (MC4DN6):
An autosomal recessive multisystem disorder with variable manifestations. Some patients present in the neonatal period with encephalomyopathic features, whereas others present later in the first year of life with developmental regression. Clinical features include microcephaly, encephalopathy, hypertrophic cardiomyopathy, persistent lactic acidosis, respiratory distress, hypotonia and seizures. Serum lactate is increased, and laboratory studies show decreased mitochondrial complex IV protein and activity levels.

More Infomation

References

de Oliveira, M. G., Tengan, C., Micheletti, C., de Macedo, P. R., Cernach, M. C. S. P., Cavole, T. R., ... & Perrone, E. (2021). A novel variant in the COX15 gene causing a fatal infantile cardioencephalomyopathy: A case report with clinical and molecular review. European Journal of Medical Genetics, 64(5), 104195.

Zhang, C., Li, N., Liu, Y. Y., Yuan, T., Yang, S., & Wang, X. P. (2021). Cox15 is a novel oncogene that required for lung cancer cell proliferation. Biochemical and Biophysical Research Communications, 578, 70-76.

Halperin, D., Drabkin, M., Wormser, O., Yogev, Y., Dolgin, V., Shorer, Z., ... & Birk, O. S. (2020). Phenotypic variability and mutation hotspot in COX15‐related Leigh syndrome. American Journal of Medical Genetics Part A, 182(6), 1506-1512.

Herwaldt, E. J., Rivett, E. D., White, A. J., & Hegg, E. L. (2018). Cox15 interacts with the cytochrome bc1 dimer within respiratory supercomplexes as well as in the absence of cytochrome c oxidase. Journal of Biological Chemistry, 293(42), 16426-16439.

Hasbrook, M., Yonekawa, Y., Van Laere, L., Shah, A. R., & Capone, A. (2017). Bilateral persistent fetal vasculature and a chromosome 10 mutation including COX15. Canadian Journal of Ophthalmology, 52(6), e203-e205.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-COX15 Recombinant Antibody (2D2)

Mouse Anti-COX15 Recombinant Antibody (EG788)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

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