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Mouse Anti-COX15 Recombinant Antibody (CBYY-C2947) (CBMAB-C4390-YY)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
CBYY-C2947
Application
WB, IP, IF, ELISA, IHC-P
Immunogen
Amino acids 89-116 within an internal region of human COX15.
Host Species
Mouse
Specificity
Human, Mouse, Rat, Dog, Cattle, Pig, Horse
Antibody Isotype
IgM, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
COX15, Cytochrome C Oxidase Assembly Homolog
Entrez Gene ID
Human10063
Mouse12856
Rat89786
UniProt ID
HumanQ14061
MouseP56394
RatQ76MV3
Alternative Names
Chorionic Gonadotropin Beta Subunit 2; Chorionic Gonadotropin, Beta Polypeptide 2;
Function
May be involved in the biosynthesis of heme A.
Biological Process
Cellular respiration Source: HGNC-UCL
Heme A biosynthetic process Source: HGNC-UCL
Heme biosynthetic process Source: Reactome
Mitochondrial electron transport, cytochrome c to oxygen Source: HGNC-UCL
Proton transmembrane transport Source: BHF-UCL
Respiratory chain complex IV assembly Source: HGNC-UCL
Respiratory gaseous exchange by respiratory system Source: UniProtKB
Cellular Location
Mitochondrion membrane
Involvement in disease
Mitochondrial complex IV deficiency, nuclear type 6 (MC4DN6):
An autosomal recessive multisystem disorder with variable manifestations. Some patients present in the neonatal period with encephalomyopathic features, whereas others present later in the first year of life with developmental regression. Clinical features include microcephaly, encephalopathy, hypertrophic cardiomyopathy, persistent lactic acidosis, respiratory distress, hypotonia and seizures. Serum lactate is increased, and laboratory studies show decreased mitochondrial complex IV protein and activity levels.

de Oliveira, M. G., Tengan, C., Micheletti, C., de Macedo, P. R., Cernach, M. C. S. P., Cavole, T. R., ... & Perrone, E. (2021). A novel variant in the COX15 gene causing a fatal infantile cardioencephalomyopathy: A case report with clinical and molecular review. European Journal of Medical Genetics, 64(5), 104195.

Zhang, C., Li, N., Liu, Y. Y., Yuan, T., Yang, S., & Wang, X. P. (2021). Cox15 is a novel oncogene that required for lung cancer cell proliferation. Biochemical and Biophysical Research Communications, 578, 70-76.

Halperin, D., Drabkin, M., Wormser, O., Yogev, Y., Dolgin, V., Shorer, Z., ... & Birk, O. S. (2020). Phenotypic variability and mutation hotspot in COX15‐related Leigh syndrome. American Journal of Medical Genetics Part A, 182(6), 1506-1512.

Herwaldt, E. J., Rivett, E. D., White, A. J., & Hegg, E. L. (2018). Cox15 interacts with the cytochrome bc1 dimer within respiratory supercomplexes as well as in the absence of cytochrome c oxidase. Journal of Biological Chemistry, 293(42), 16426-16439.

Hasbrook, M., Yonekawa, Y., Van Laere, L., Shah, A. R., & Capone, A. (2017). Bilateral persistent fetal vasculature and a chromosome 10 mutation including COX15. Canadian Journal of Ophthalmology, 52(6), e203-e205.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-COX15 Recombinant Antibody (EG788) (CAT#: V2LY-1206-LY846)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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