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Rabbit Anti-CPE Recombinant Antibody (EG801) (CBMAB-EN957-LY)

The product is antibody recognizes CPE. The antibody EG801 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:5000.
See all CPE antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG801
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:5000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human CPE.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Carboxypeptidase E
Introduction
CPE (Carboxypeptidase E) is a Protein Coding gene. Diseases associated with CPE include Hyperproinsulinemia and Phlebotomus Fever. Among its related pathways are Peptide hormone metabolism and Allograft rejection. Gene Ontology (GO) annotations related to this gene include cell adhesion molecule binding and carboxypeptidase activity. An important paralog of this gene is CPD.
Entrez Gene ID
Human1363
Mouse12876
Rat25669
UniProt ID
HumanP16870
MouseQ00493
RatP15087
Alternative Names
Carboxypeptidase E; Enkephalin Convertase; Carboxypeptidase H; Cobalt-Stimulated Chromaffin Granule Carboxypeptidase; Insulin Granule-Associated Carboxypeptidase; Prohormone-Processing Carboxypeptidase; EC 3.4.17.10; CPH; EC 3.4.17;
Function
Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage.
Biological Process
Cardiac left ventricle morphogenesis Source: BHF-UCL
Cellular protein modification process Source: UniProtKB
Neuropeptide signaling pathway Source: UniProtKB
Peptide metabolic process Source: GO_Central
Protein localization to membrane Source: BHF-UCL
Protein processing Source: GO_Central
Wnt signaling pathway Source: CACAO
Cellular Location
Isoform 1: Secreted; Secretory vesicle; Secretory vesicle membrane. Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions.

Li, N., Teng, S. W., Zhao, L., Li, J. R., Xu, J. L., Shuai, J. C., & Chen, Z. Y. (2021). Carboxypeptidase E regulates activity-dependent TrkB neuronal surface insertion and hippocampal memory. Journal of Neuroscience, 41(33), 6987-7002.

Moon, Y., Moon, R., Roh, H., Chang, S., Lee, S., & Park, H. (2020). HIF-1α-dependent induction of carboxypeptidase A4 and carboxypeptidase E in hypoxic human adipose-derived stem cells. Molecules and Cells, 43(11), 945.

Chougule, A., Kolli, V., Baroi, S., Ebraheim, N., Czernik, P. J., Loh, Y. P., & Lecka‐Czernik, B. (2020). Nonenzymatic and trophic activities of carboxypeptidase e regulate bone mass and bioenergetics of skeletal stem cells in mice. JBMR plus, 4(9), e10392.

Liang, C., Carrel, D., Omelchenko, A., Kim, H., Patel, A., Fanget, I., & Firestein, B. L. (2019). Cortical neuron migration and dendrite morphology are regulated by carboxypeptidase E. Cerebral Cortex, 29(7), 2890-2903.

Fan, S., Gao, X., Chen, P., & Li, X. (2019). Carboxypeptidase E-ΔN promotes migration, invasiveness, and epithelial–mesenchymal transition of human osteosarcoma cells via the Wnt–β-catenin pathway. Biochemistry and Cell Biology, 97(4), 446-453.

Yang, X., Lou, H., Chen, Y. T., Huang, S. F., & Loh, Y. P. (2019). A novel 40kDa N-terminal truncated Carboxypeptidase E splice variant: Cloning, cDNA sequence analysis and role in regulation of metastatic genes in human cancers. Genes & cancer, 10(5-6), 160.

Xiao, L., Yang, X., & Loh, Y. P. (2019). Neurotrophic, gene regulation, and cognitive functions of carboxypeptidase E-neurotrophic factor-α1 and its variants. Frontiers in Neuroscience, 13, 243.

Fricker, L. D. (2018). Carboxypeptidase E and the identification of novel neuropeptides as potential therapeutic targets. Advances in pharmacology, 82, 85-102.

Ji, L., Wu, H. T., Qin, X. Y., & Lan, R. (2017). Dissecting carboxypeptidase E: properties, functions and pathophysiological roles in disease. Endocrine Connections, 6(4), R18-R38.

Cong, L., Cheng, Y., Cawley, N. X., Murthy, S. R., & Loh, Y. P. (2017). A novel single nucleotide T980C polymorphism in the human carboxypeptidase E gene results in loss of neuroprotective function. PLoS One, 12(1), e0170169.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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