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Rabbit Anti-CPLX2 Recombinant Antibody (021) (CBMAB-C1678-LY)

This product is antibody recognizes CPLX2. The antibody 021 immunoassay techniques such as: ICC/IF, IF.
See all CPLX2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
021
Antibody Isotype
IgG
Application
ICC/IF, IF

Basic Information

Immunogen
Recombinant Human Complexin-2 / CPLX2 Protein
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Complexin 2
Introduction
CPLX2 (Complexin 2) is a Protein Coding gene. Diseases associated with CPLX2 include Huntington Disease and Schizophrenia. Among its related pathways are Synaptic vesicle cycle and Neuroscience. Gene Ontology (GO) annotations related to this gene include syntaxin binding and SNARE binding. An important paralog of this gene is CPLX1.
Entrez Gene ID
10814
UniProt ID
Q6PUV4
Alternative Names
Complexin 2; Complexin II; CPX II; Complexin-2; Synaphin 1; Synaphin-1;
Function
Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity).
Biological Process
Cell differentiation Source: UniProtKB-KW
Mast cell degranulation Source: UniProtKB-KW
Nervous system development Source: UniProtKB-KW
Positive regulation of synaptic plasticity Source: UniProtKB
Regulation of exocytosis Source: ParkinsonsUK-UCL
Regulation of neurotransmitter secretion Source: GO_Central
Regulation of synaptic vesicle fusion to presynaptic active zone membrane Source: Ensembl
Synaptic vesicle exocytosis Source: GO_Central
Vesicle docking involved in exocytosis Source: ProtInc
Cellular Location
Nucleus; Cytosol; Presynapse; Perikaryon. Translocated from the perikaryon to the presynaptic terminals during maturation of neuronal cells. In mast cells, cytosol and nucleus. Becomes enriched near plasma membrane following stimulation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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