CPLX2

CPLX2 (Complexin 2) is a Protein Coding gene. Diseases associated with CPLX2 include Huntington Disease and Schizophrenia. Among its related pathways are Synaptic vesicle cycle and Neuroscience. Gene Ontology (GO) annotations related to this gene include syntaxin binding and SNARE binding. An important paralog of this gene is CPLX1.

Full Name

Complexin 2

Function

Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity).

Biological Process

Cell differentiation Source: UniProtKB-KW
Mast cell degranulation Source: UniProtKB-KW
Nervous system development Source: UniProtKB-KW
Positive regulation of synaptic plasticity Source: UniProtKB
Regulation of exocytosis Source: ParkinsonsUK-UCL
Regulation of neurotransmitter secretion Source: GO_Central
Regulation of synaptic vesicle fusion to presynaptic active zone membrane Source: Ensembl
Synaptic vesicle exocytosis Source: GO_Central
Vesicle docking involved in exocytosis Source: ProtInc

Cellular Location

Nucleus; Cytosol; Presynapse; Perikaryon. Translocated from the perikaryon to the presynaptic terminals during maturation of neuronal cells. In mast cells, cytosol and nucleus. Becomes enriched near plasma membrane following stimulation.