Mouse Anti-CPLX2 Recombinant Antibody (CBXC-1753) (V2LY-1206-LY958)

Name: Mouse Anti-CPLX2 Recombinant Antibody (CBXC-1753)
SKU: V2LY-1206-LY958
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXC-1753

Application

ELISA, IF, IHC

Immunogen

CPLX2 Fusion Protein.

Host Species

Mouse

Specificity

Human, Mouse, Rat, Pig

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
IF(ICC)	1:500
WB	1:1,500
IHC	1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Complexin 2

Entrez Gene ID

Human	10814
Mouse	12890
Rat	116657

UniProt ID

Human	Q6PUV4
Mouse	P84086
Rat	P84087

Function

Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity).

Biological Process

Cell differentiation Source: UniProtKB-KW
Mast cell degranulation Source: UniProtKB-KW
Nervous system development Source: UniProtKB-KW
Positive regulation of synaptic plasticity Source: UniProtKB
Regulation of exocytosis Source: ParkinsonsUK-UCL
Regulation of neurotransmitter secretion Source: GO_Central
Regulation of synaptic vesicle fusion to presynaptic active zone membrane Source: Ensembl
Synaptic vesicle exocytosis Source: GO_Central
Vesicle docking involved in exocytosis Source: ProtInc

Cellular Location

Nucleus; Cytosol; Presynapse; Perikaryon. Translocated from the perikaryon to the presynaptic terminals during maturation of neuronal cells. In mast cells, cytosol and nucleus. Becomes enriched near plasma membrane following stimulation.

Lux, U. T., Ehrenberg, J., Joachimsthaler, A., Atorf, J., Pircher, B., Reim, K., ... & Brandstätter, J. H. (2021). Cell Types and Synapses Expressing the SNARE Complex Regulating Proteins Complexin 1 and Complexin 2 in Mammalian Retina. International Journal of Molecular Sciences, 22(15), 8131.

Tsuru, E., Oryu, K., Sawada, K., Nishihara, M., & Tsuda, M. (2019). Complexin 2 regulates secretion of immunoglobulin in antibody‐secreting cells. Immunity, inflammation and disease, 7(4), 318-325.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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