Human Recombinant CPLX2 protein, His Tag (V2LY-0526-LY3349)

Name: Human Recombinant CPLX2 protein, His Tag
SKU: V2LY-0526-LY3349
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant CPLX2 protein, His Tag consist of Amino Acid: 2-134 and predicts a molecular mass of 16.8 kDa.

Molecule Mass

16.8 kDa

Sequence

Amino Acid: 2-134

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Complexin 2

Function

Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity).

Biological Process

Cell differentiation Source: UniProtKB-KW
Mast cell degranulation Source: UniProtKB-KW
Nervous system development Source: UniProtKB-KW
Positive regulation of synaptic plasticity Source: UniProtKB
Regulation of exocytosis Source: ParkinsonsUK-UCL
Regulation of neurotransmitter secretion Source: GO_Central
Regulation of synaptic vesicle fusion to presynaptic active zone membrane Source: Ensembl
Synaptic vesicle exocytosis Source: GO_Central
Vesicle docking involved in exocytosis Source: ProtInc

Cellular Location

Nucleus; Cytosol; Presynapse; Perikaryon. Translocated from the perikaryon to the presynaptic terminals during maturation of neuronal cells. In mast cells, cytosol and nucleus. Becomes enriched near plasma membrane following stimulation.

Lux, U. T., Ehrenberg, J., Joachimsthaler, A., Atorf, J., Pircher, B., Reim, K., ... & Brandstätter, J. H. (2021). Cell Types and Synapses Expressing the SNARE Complex Regulating Proteins Complexin 1 and Complexin 2 in Mammalian Retina. International Journal of Molecular Sciences, 22(15), 8131.

Tsuru, E., Oryu, K., Sawada, K., Nishihara, M., & Tsuda, M. (2019). Complexin 2 regulates secretion of immunoglobulin in antibody‐secreting cells. Immunity, inflammation and disease, 7(4), 318-325.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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