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Mouse Anti-CPLX3 Recombinant Antibody (CBFYC-2158) (CBMAB-C2226-FY)

This product is mouse antibody that recognizes CPLX3. The antibody CBFYC-2158 can be used for immunoassay techniques such as: WB, IHC.
See all CPLX3 antibodies

Summary

Host Animal
Mouse
Specificity
Rat, Mouse
Clone
CBFYC-2158
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Full-length protein of mouse complexin 3
Specificity
Rat, Mouse
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Complexin 3
Introduction
CPLX3 (Complexin 3) is a Protein Coding gene. Diseases associated with CPLX3 include Acute Dacryocystitis and Chromosome 15Q24 Deletion Syndrome. Among its related pathways are Synaptic vesicle cycle. Gene Ontology (GO) annotations related to this gene include syntaxin binding and neurotransmitter transporter activity. An important paralog of this gene is CPLX4.
Entrez Gene ID
Mouse235415
Rat501005
UniProt ID
MouseQ8R1B5
RatD4ABY0
Alternative Names
ERGL; CpxIII; Lamn1l; Lman1l; BC016632; ERGIC-53L
Function
Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity).

Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity).

Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (By similarity).

Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca2+ vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca2+ vesicle release (By similarity).
Biological Process
Insulin secretion Source: Ensembl
Regulation of neurotransmitter secretion Source: GO_Central
Regulation of synaptic vesicle fusion to presynaptic active zone membrane Source: Ensembl
Response to stimulus Source: UniProtKB-KW
Synaptic vesicle exocytosis Source: GO_Central
Visual perception Source: UniProtKB-KW
Cellular Location
Cell membrane; Synapse. Enriched at the synaptic terminal (By similarity). Localized at glycinergic synaptic contacts of AII amacrine cells with OFF cone bipolar cells in the OFF sublamina of the retina inner nuclear layer (By similarity).
PTM
Farnesylation mediates presynaptic targeting.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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