CPLX3

CPLX3 (Complexin 3) is a Protein Coding gene. Diseases associated with CPLX3 include Acute Dacryocystitis and Chromosome 15Q24 Deletion Syndrome. Among its related pathways are Synaptic vesicle cycle. Gene Ontology (GO) annotations related to this gene include syntaxin binding and neurotransmitter transporter activity. An important paralog of this gene is CPLX4.

Full Name

Complexin 3

Function

Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity).

Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity).

Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (By similarity).

Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca2+ vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca2+ vesicle release (By similarity).

Biological Process

Insulin secretion Source: Ensembl
Regulation of neurotransmitter secretion Source: GO_Central
Regulation of synaptic vesicle fusion to presynaptic active zone membrane Source: Ensembl
Response to stimulus Source: UniProtKB-KW
Synaptic vesicle exocytosis Source: GO_Central
Visual perception Source: UniProtKB-KW

Cellular Location

Cell membrane; Synapse. Enriched at the synaptic terminal (By similarity). Localized at glycinergic synaptic contacts of AII amacrine cells with OFF cone bipolar cells in the OFF sublamina of the retina inner nuclear layer (By similarity).

PTM

Farnesylation mediates presynaptic targeting.