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Mouse Anti-CPNE3 Recombinant Antibody (4F4) (CBMAB-C6933-LY)

This product is antibody recognizes CPNE3. The antibody 4F4 immunoassay techniques such as: ELISA, WB.
See all CPNE3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4F4
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
CPNE3 (NP_003900.1, 164 a.a. ~ 244 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: EFHKQTSDGN WLMVHRTEVV KNNLNPVWRP FKISLNSLCY GDMDKTIKVE CYDYDNDGSH DLIGTFQTTM TKLKEASRSS P
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
copine III
Introduction
CPNE3 (Copine 3) is a Protein Coding gene. Among its related pathways are Innate Immune System and Metabolism. Gene Ontology (GO) annotations related to this gene include transporter activity. An important paralog of this gene is CPNE1.
Entrez Gene ID
8895
UniProt ID
O75131
Alternative Names
Copine 3; Copine III; CPN3; Copine-3; KIAA0636; PRO1071;
Function
Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation (PubMed:20010870).
Biological Process
Cellular response to calcium ion Source: UniProtKB
Cellular response to growth factor stimulus Source: UniProtKB
ERBB2 signaling pathway Source: UniProtKB
Glycerophospholipid biosynthetic process Source: Reactome
Neutrophil degranulation Source: Reactome
Positive regulation of cell migration Source: UniProtKB
Cellular Location
Cytoplasm; Nucleus; Cell membrane; Cell junction; Focal adhesion. Associates to the membrane in a calcium-dependent manner (PubMed:20010870). Translocates to the cell membrane and the nucleus in a calcium- or growth factor heregulin-dependent manner (PubMed:21087455, PubMed:20010870). Colocalizes with the tyrosine phosphorylated ERBB2 form at cell membrane and focal adhesions in a calcium- or growth factor heregulin-dependent manner (PubMed:20010870).
PTM
Phosphorylated on serine and threonine residues (PubMed:11041869).

Zhang, X., Han, X., & Zhang, Y. (2022). CPNE3 interaction with RACK1 protects against myocardial ischemia/reperfusion injury. Experimental and Therapeutic Medicine, 23(2), 1-10.

El-Huneidi, W., Anjum, S., Mohammed, A. K., Unnikannan, H., Saeed, R., Bajbouj, K., ... & Taneera, J. (2021). Copine 3 “CPNE3” is a novel regulator for insulin secretion and glucose uptake in pancreatic β-cells. Scientific reports, 11(1), 1-9.

Shi, D., Lin, B., Lai, J., Li, K., & Feng, Y. (2021). Upregulation of CPNE3 suppresses invasion, migration and proliferation of glioblastoma cells through FAK pathway inactivation. Journal of Molecular Histology, 52(3), 589-596.

Zhang, D., Wang, X., Wang, X., Wang, Z., Ma, S., Zhang, C., ... & Jia, W. (2021). CPNE3 regulates the cell proliferation and apoptosis in human Glioblastoma via the activation of PI3K/AKT signaling pathway. Journal of Cancer, 12(24), 7277.

Sun, B., Li, Y., Zhou, Y., Ng, T. K., Zhao, C., Gan, Q., ... & Xiang, J. (2019). Circulating exosomal CPNE3 as a diagnostic and prognostic biomarker for colorectal cancer. Journal of cellular physiology, 234(2), 1416-1425.

Tan, B., Liu, L., Yang, Y., Liu, Q., Yang, L., & Meng, F. (2019). Low CPNE3 expression is associated with risk of acute myocardial infarction: A feasible genetic marker of acute myocardial infarction in patients with stable coronary artery disease. Cardiology Journal, 26(2), 186-193.

Lin, H., Zhang, X., Liao, L., Yu, T., Li, J., Pan, H., ... & Yao, M. (2018). CPNE3 promotes migration and invasion in non-small cell lung cancer by interacting with RACK1 via FAK signaling activation. Journal of Cancer, 9(22), 4215.

Chen, Z., Jiang, Z., Zhang, W., & He, B. (2018). Silencing the expression of copine-III enhances the sensitivity of hepatocellular carcinoma cells to the molecular targeted agent sorafenib. Cancer Management and Research, 10, 3057.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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