CPNE3

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a protein which contains two type II C2 domains in the amino-terminus and an A domain-like sequence in the carboxy-terminus. The A domain mediates interactions between integrins and extracellular ligands. [provided by RefSeq]

Full Name

copine III

Function

Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation (PubMed:20010870).

Biological Process

Cellular response to calcium ion Source: UniProtKB
Cellular response to growth factor stimulus Source: UniProtKB
ERBB2 signaling pathway Source: UniProtKB
Glycerophospholipid biosynthetic process Source: Reactome
Neutrophil degranulation Source: Reactome
Positive regulation of cell migration Source: UniProtKB

Cellular Location

Cytoplasm; Nucleus; Cell membrane; Cell junction; Focal adhesion. Associates to the membrane in a calcium-dependent manner (PubMed:20010870). Translocates to the cell membrane and the nucleus in a calcium- or growth factor heregulin-dependent manner (PubMed:21087455, PubMed:20010870). Colocalizes with the tyrosine phosphorylated ERBB2 form at cell membrane and focal adhesions in a calcium- or growth factor heregulin-dependent manner (PubMed:20010870).

PTM

Phosphorylated on serine and threonine residues (PubMed:11041869).