Mouse Anti-CPNE3 Recombinant Antibody (C6933) (V2LY-1206-LY971)

Name: Mouse Anti-CPNE3 Recombinant Antibody (C6933)
SKU: V2LY-1206-LY971
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

C6933

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 151-189 within an internal region of human copine 3.

Host Species

Mouse

Specificity

Human, Mouse, Rat, Dog, Cattle, Pig, Horse

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.1% gelatin

Preservative

0.09% sodium azide

Concentration

0.2 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

copine III

Entrez Gene ID

Human	8895
Mouse	70568
Rat	313087

UniProt ID

Human	O75131
Mouse	Q8BT60
Rat	D3ZLA3

Function

Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation (PubMed:20010870).

Biological Process

Cellular response to calcium ion Source: UniProtKB
Cellular response to growth factor stimulus Source: UniProtKB
ERBB2 signaling pathway Source: UniProtKB
Glycerophospholipid biosynthetic process Source: Reactome
Neutrophil degranulation Source: Reactome
Positive regulation of cell migration Source: UniProtKB

Cellular Location

Cytoplasm; Nucleus; Cell membrane; Cell junction; Focal adhesion. Associates to the membrane in a calcium-dependent manner (PubMed:20010870). Translocates to the cell membrane and the nucleus in a calcium- or growth factor heregulin-dependent manner (PubMed:21087455, PubMed:20010870). Colocalizes with the tyrosine phosphorylated ERBB2 form at cell membrane and focal adhesions in a calcium- or growth factor heregulin-dependent manner (PubMed:20010870).

PTM

Phosphorylated on serine and threonine residues (PubMed:11041869).

Zhang, X., Han, X., & Zhang, Y. (2022). CPNE3 interaction with RACK1 protects against myocardial ischemia/reperfusion injury. Experimental and Therapeutic Medicine, 23(2), 1-10.

El-Huneidi, W., Anjum, S., Mohammed, A. K., Unnikannan, H., Saeed, R., Bajbouj, K., ... & Taneera, J. (2021). Copine 3 “CPNE3” is a novel regulator for insulin secretion and glucose uptake in pancreatic β-cells. Scientific reports, 11(1), 1-9.

Shi, D., Lin, B., Lai, J., Li, K., & Feng, Y. (2021). Upregulation of CPNE3 suppresses invasion, migration and proliferation of glioblastoma cells through FAK pathway inactivation. Journal of Molecular Histology, 52(3), 589-596.

Zhang, D., Wang, X., Wang, X., Wang, Z., Ma, S., Zhang, C., ... & Jia, W. (2021). CPNE3 regulates the cell proliferation and apoptosis in human Glioblastoma via the activation of PI3K/AKT signaling pathway. Journal of Cancer, 12(24), 7277.

Sun, B., Li, Y., Zhou, Y., Ng, T. K., Zhao, C., Gan, Q., ... & Xiang, J. (2019). Circulating exosomal CPNE3 as a diagnostic and prognostic biomarker for colorectal cancer. Journal of cellular physiology, 234(2), 1416-1425.

Tan, B., Liu, L., Yang, Y., Liu, Q., Yang, L., & Meng, F. (2019). Low CPNE3 expression is associated with risk of acute myocardial infarction: A feasible genetic marker of acute myocardial infarction in patients with stable coronary artery disease. Cardiology Journal, 26(2), 186-193.

Lin, H., Zhang, X., Liao, L., Yu, T., Li, J., Pan, H., ... & Yao, M. (2018). CPNE3 promotes migration and invasion in non-small cell lung cancer by interacting with RACK1 via FAK signaling activation. Journal of Cancer, 9(22), 4215.

Chen, Z., Jiang, Z., Zhang, W., & He, B. (2018). Silencing the expression of copine-III enhances the sensitivity of hepatocellular carcinoma cells to the molecular targeted agent sorafenib. Cancer Management and Research, 10, 3057.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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