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Mouse Anti-CPSF4 Recombinant Antibody (CBXC-1788) (CBMAB-C3774-CQ)

This product is a mouse antibody that recognizes CPSF4. The antibody CBXC-1788 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all CPSF4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-1788
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cleavage And Polyadenylation Specific Factor 4
Introduction
CPSF4 (Cleavage And Polyadenylation Specific Factor 4) is a Protein Coding gene. Diseases associated with CPSF4 include Influenza and Benign Essential Hypertension. Among its related pathways are mRNA Splicing - Major Pathway and Transport of the SLBP independent Mature mRNA. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is CPSF4L.
Entrez Gene ID
10898
UniProt ID
O95639
Alternative Names
Cleavage And Polyadenylation Specific Factor 4; Cleavage And Polyadenylation Specificity Factor 30 KDa Subunit; Cleavage And Polyadenylation Specific Factor 4, 30kDa; NS1 Effector Domain-Binding Protein 1; CPSF 30 KDa Subunit; No Arches Homolog; CPSF30;
Function
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
Biological Process
modification by virus of host mRNA processing Source: Reactome
mRNA 3'-end processing Source: Reactome
mRNA export from nucleus Source: Reactome
mRNA splicing, via spliceosome Source: Reactome
Pre-mRNA cleavage required for polyadenylation Source: GO_Central
Termination of RNA polymerase II transcription Source: Reactome
tRNA splicing, via endonucleolytic cleavage and ligation Source: Reactome
Cellular Location
Nucleus

Wang, X., Dong, J., Li, X., Cheng, Z., & Zhu, Q. (2021). CPSF4 regulates circRNA formation and microRNA mediated gene silencing in hepatocellular carcinoma. Oncogene, 40(25), 4338-4351.

Lee, K., Zheng, Q., Lu, Q., Xu, F., Qin, G., Zhai, Q., ... & Wang, S. (2021). CPSF4 promotes triple negative breast cancer metastasis by upregulating MDM4. Signal transduction and targeted therapy, 6(1), 1-3.

Zhang, M., Lin, H., Ge, X., & Xu, Y. (2021). Overproduced CPSF4 promotes cell proliferation and invasion via PI3K-AKT signaling pathway in oral squamous cell carcinoma. Journal of Oral and Maxillofacial Surgery, 79(5), 1177-e1.

Wang, X., Jiang, G., Ren, W., Wang, B., Yang, C., & Li, M. (2020). LncRNA NEAT1 regulates 5-Fu sensitivity, apoptosis and invasion in colorectal cancer through the MiR-150-5p/CPSF4 axis. OncoTargets and therapy, 13, 6373.

Yang, Q., Fan, W., Zheng, Z., Lin, S., Liu, C., Wang, R., ... & Wu, X. (2019). Cleavage and polyadenylation specific factor 4 promotes colon cancer progression by transcriptionally activating hTERT. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1866(10), 1533-1543.

Wu, J., Miao, J., Ding, Y., Zhang, Y., Huang, X., Zhou, X., & Tang, R. (2019). MiR-4458 inhibits breast cancer cell growth, migration, and invasiveness by targeting CPSF4. Biochemistry and Cell Biology, 97(6), 722-730.

Dubois, J., Traversier, A., Julien, T., Padey, B., Lina, B., Bourdon, J. C., ... & Terrier, O. (2019). The nonstructural NS1 protein of influenza viruses modulates TP53 splicing through host factor CPSF4. Journal of virology, 93(7), e02168-18.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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