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Rabbit Anti-CRCP Recombinant Antibody (EPR9670(B)) (CBMAB-1428-CN)

This product is a rabbit antibody that recognizes CRCP of human. The antibody EPR9670(B) can be used for immunoassay techniques such as: IF, IHC-P, IP, WB.
See all CRCP antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EPR9670(B)
Antibody Isotype
IgG
Application
IF, IHC-P, IP, WB

Basic Information

Immunogen
Synthetic peptide corresponding to Human CRCP aa. 1-100 (N terminal).
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
59% PBS, 40% Glycerol, 0.05% BSA
Preservative
0.01% Sodium azide
Concentration
0.516 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CGRP Receptor Component
Introduction
This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. This protein plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. This protein acts as nuclear and cytosolic DNA sensor involved in innate immune response.
Entrez Gene ID
Human27297
Mouse12909
Rat114205
UniProt ID
HumanO75575
MouseO35427
RatQ8VHM6
Alternative Names
RCP; RCP9; RPC9; CGRPRCP; CGRP-RCP
Function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).

Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.
Biological Process
Defense response to virus Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
Neuropeptide signaling pathway Source: Ensembl
Positive regulation of type I interferon production Source: Reactome
Transcription by RNA polymerase III Source: UniProtKB
Transcription initiation from RNA polymerase III promoter Source: GO_Central
Cellular Location
Cell membrane; Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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