CRCP

CRCP (CGRP Receptor Component) is a Protein Coding gene. Among its related pathways are Innate Immune System and RNA Polymerase III Transcription Initiation. Gene Ontology (GO) annotations related to this gene include nucleotide binding and RNA polymerase III activity.

Full Name

CGRP Receptor Component

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).

Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.

Biological Process

Defense response to virus Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
Neuropeptide signaling pathway Source: Ensembl
Positive regulation of type I interferon production Source: Reactome
Transcription by RNA polymerase III Source: UniProtKB
Transcription initiation from RNA polymerase III promoter Source: GO_Central

Cellular Location

Cell membrane; Nucleus