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Mouse Anti-CRHBP Recombinant Antibody (CBYY-C2927) (CBMAB-C4370-YY)

This product is mouse antibody that recognizes CRHBP. The antibody CBYY-C2927 can be used for immunoassay techniques such as: ELISA, WB
See all CRHBP antibodies

Summary

Host Animal
Mouse
Specificity
Horse
Clone
CBYY-C2927
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
NS0-derived rhCRHBP
Specificity
Horse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein G purified
Preservative
50% glycerol, PBS, 5% trehalose
Concentration
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Corticotropin Releasing Hormone Binding Protein
Entrez Gene ID
100073275
UniProt ID
F6QCN4
Alternative Names
Ciliary Neurotrophic Factor; HCNTF;
Function
Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
Biological Process
Behavioral response to ethanol Source: UniProtKB
Cellular response to calcium ion Source: UniProtKB
Cellular response to cAMP Source: UniProtKB
Cellular response to cocaine Source: UniProtKB
Cellular response to drug Source: UniProtKB
Cellular response to estradiol stimulus Source: UniProtKB
Cellular response to estrogen stimulus Source: UniProtKB
Cellular response to gonadotropin-releasing hormone Source: UniProtKB
Cellular response to potassium ion Source: UniProtKB
Cellular response to tumor necrosis factor Source: UniProtKB
Female pregnancy Source: UniProtKB
Hormone-mediated signaling pathway Source: UniProtKB
Inflammatory response Source: UniProtKB
Learning or memory Source: UniProtKB
Negative regulation of corticotropin-releasing hormone receptor activity Source: UniProtKB
Negative regulation of corticotropin secretion Source: UniProtKB
Regulated exocytosis Source: UniProtKB
Regulation of cellular response to stress Source: UniProtKB
Regulation of corticotropin secretion Source: UniProtKB
Regulation of NMDA receptor activity Source: UniProtKB
Signal transduction Source: UniProtKB
Synaptic transmission, dopaminergic Source: UniProtKB
Cellular Location
Secreted

Adachi, N., Suzuki, S., Matsuoka, H., Fushimi, S., Ono, J., Ohta, K. I., ... & Koshimizu, H. (2018). Corticotropin‐releasing hormone‐binding protein is up‐regulated by brain‐derived neurotrophic factor and is secreted in an activity‐dependent manner in rat cerebral cortical neurons. Journal of neurochemistry, 146(1), 99-110.

Fabbri, C., Lewis, C. M., Perlis, R. H., & Uher, R. (2018). No Association Between Antidepressant Efficacy and rs28365143 in Corticotropin-Releasing Hormone Binding Protein in a Large Meta-Analysis. American Journal of Psychiatry, 175(6), 575-576.

Xia, H. B., Wang, H. J., Fu, L. Q., Wang, S. B., Li, L., Ru, G. Q., ... & Huang, D. S. (2018). Decreased CRHBP expression is predictive of poor prognosis in patients with hepatocellular carcinoma. Oncology Letters, 16(3), 3681-3689.

Haass-Koffler, C. L. (2018). The corticotropin releasing factor binding protein: A strange case of Dr. Jekyll and Mr. Hyde in the stress system?. Alcohol, 72, 3-8.

O’Connell, C. P., Goldstein-Piekarski, A. N., Nemeroff, C. B., Schatzberg, A. F., Debattista, C., Carrillo-Roa, T., ... & Williams, L. M. (2018). Antidepressant outcomes predicted by genetic variation in corticotropin-releasing hormone binding protein. American Journal of Psychiatry, 175(3), 251-261.

Kalin, N. H. (2018). Corticotropin-Releasing Hormone Binding Protein: Stress, Psychopathology, and Antidepressant Treatment Response. American Journal of Psychiatry, 175(3), 204-206.

Ketchesin, K. D., Stinnett, G. S., & Seasholtz, A. F. (2017). Corticotropin-releasing hormone-binding protein and stress: from invertebrates to humans. Stress, 20(5), 449-464.

Su, F., Xia, Y., Huang, M., Zhang, L., & Chen, L. (2017). Up-regulation of corticotropin releasing hormone is associated with the downregulation of corticotropin releasing hormone binding protein and up-regulation of IL-33 and IL-8 expression in psoriasis. Tropical Journal of Pharmaceutical Research, 16(11), 2595-2600.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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