Mouse Anti-CRLS1 Recombinant Antibody (CBXC-1776) (CBMAB-C5870-CQ)

This product is a mouse antibody that recognizes CRLS1. The antibody CBXC-1776 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all CRLS1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBXC-1776

Antibody Isotype

IgG

Application

WB, IP, IF, ELISA

Basic Information

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Cardiolipin Synthase 1

Introduction

CRLS1 (Cardiolipin Synthase 1) is a Protein Coding gene. Diseases associated with CRLS1 include Catastrophic Antiphospholipid Syndrome. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. Gene Ontology (GO) annotations related to this gene include phosphotransferase activity, for other substituted phosphate groups and CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity.

Entrez Gene ID

54675

UniProt ID

Q9UJA2

Alternative Names

Cardiolipin Synthase 1; C20orf155; CLS1; CLS; Chromosome 20 Open Reading Frame 155; Cardiolipin Synthase (CMP-Forming);

Function

Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions.

Biological Process

Cardiolipin biosynthetic process Source: GO_Central
Glycerophospholipid biosynthetic process Source: GO_Central
Phosphatidylglycerol acyl-chain remodeling Source: Reactome
Response to phosphatidylethanolamine Source: Ensembl
Response to thyroxine Source: Ensembl

Cellular Location

Mitochondrion inner membrane

References

Lee, R. G., Balasubramaniam, S., Stentenbach, M., Kralj, T., McCubbin, T., Padman, B., ... & Care4Rare Canada Consortium. (2022). Deleterious variants in CRLS1 lead to cardiolipin deficiency and cause an autosomal recessive multi-system mitochondrial disease. Human Molecular Genetics.

Ma, X., Liu, Y., Tian, H., Zhang, B., Wang, M., & Gao, X. (2021). LINC01272 suppressed cell multiplication and induced apoptosis via regulating MiR-7-5p/CRLS1 axis in lung cancer.

Tu, C., Xiong, H., Hu, Y., Wang, W., Mei, G., Wang, H., ... & Mei, Z. (2020). Cardiolipin synthase 1 ameliorates NASH through activating transcription factor 3 transcriptional inactivation. Hepatology, 72(6), 1949-1967.

Yin, J., Liu, Q., Chen, C., & Liu, W. (2019). Small regulatory polypeptide of amino acid response negatively relates to poor prognosis and controls hepatocellular carcinoma progression via regulating microRNA‐5581‐3p/human cardiolipin synthase 1. Journal of Cellular Physiology, 234(10), 17589-17599.

Feng, H. M., Zhao, Y., Zhang, J. P., Zhang, J. H., Jiang, P., Li, B., & Wang, C. (2018). Expression and potential mechanism of metabolism-related genes and CRLS1 in non-small cell lung cancer. Oncology letters, 15(2), 2661-2668.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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