CRLS1

CRLS1 (Cardiolipin Synthase 1) is a Protein Coding gene. Diseases associated with CRLS1 include Catastrophic Antiphospholipid Syndrome. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. Gene Ontology (GO) annotations related to this gene include phosphotransferase activity, for other substituted phosphate groups and CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity.

Full Name

Cardiolipin Synthase 1

Function

Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions.

Biological Process

Cardiolipin biosynthetic process Source: GO_Central
Glycerophospholipid biosynthetic process Source: GO_Central
Phosphatidylglycerol acyl-chain remodeling Source: Reactome
Response to phosphatidylethanolamine Source: Ensembl
Response to thyroxine Source: Ensembl

Cellular Location

Mitochondrion inner membrane