Mouse Anti-CRLS1 Recombinant Antibody (CBXC-1776) (V2LY-1206-LY1203)

Name: Mouse Anti-CRLS1 Recombinant Antibody (CBXC-1776)
SKU: V2LY-1206-LY1203
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXC-1776

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 88-301 mapping at the C-terminus of human CLS1.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.1% gelatin

Preservative

0.09% sodium azide

Concentration

0.2 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Cardiolipin Synthase 1

Entrez Gene ID

54675

UniProt ID

Q9UJA2

Function

Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions.

Biological Process

Cardiolipin biosynthetic process Source: GO_Central
Glycerophospholipid biosynthetic process Source: GO_Central
Phosphatidylglycerol acyl-chain remodeling Source: Reactome
Response to phosphatidylethanolamine Source: Ensembl
Response to thyroxine Source: Ensembl

Cellular Location

Mitochondrion inner membrane

Lee, R. G., Balasubramaniam, S., Stentenbach, M., Kralj, T., McCubbin, T., Padman, B., ... & Care4Rare Canada Consortium. (2022). Deleterious variants in CRLS1 lead to cardiolipin deficiency and cause an autosomal recessive multi-system mitochondrial disease. Human Molecular Genetics.

Ma, X., Liu, Y., Tian, H., Zhang, B., Wang, M., & Gao, X. (2021). LINC01272 suppressed cell multiplication and induced apoptosis via regulating MiR-7-5p/CRLS1 axis in lung cancer.

Tu, C., Xiong, H., Hu, Y., Wang, W., Mei, G., Wang, H., ... & Mei, Z. (2020). Cardiolipin synthase 1 ameliorates NASH through activating transcription factor 3 transcriptional inactivation. Hepatology, 72(6), 1949-1967.

Yin, J., Liu, Q., Chen, C., & Liu, W. (2019). Small regulatory polypeptide of amino acid response negatively relates to poor prognosis and controls hepatocellular carcinoma progression via regulating microRNA‐5581‐3p/human cardiolipin synthase 1. Journal of Cellular Physiology, 234(10), 17589-17599.

Feng, H. M., Zhao, Y., Zhang, J. P., Zhang, J. H., Jiang, P., Li, B., & Wang, C. (2018). Expression and potential mechanism of metabolism-related genes and CRLS1 in non-small cell lung cancer. Oncology letters, 15(2), 2661-2668.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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