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Mouse Anti-CRYM Recombinant Antibody (1B5) (CBMAB-C3651-LY)

This product is antibody recognizes CRYM. The antibody 1B5 immunoassay techniques such as: IF, IHC-F, WB.
See all CRYM antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1B5
Antibody Isotype
IgG2a
Application
IF, IHC-F, WB

Basic Information

Immunogen
CRYM antibody was raised in mouse using a full length recombinant protein of human CRYM (NP_001879) produced in HEK293T cells, as the immunogen
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.5 mg/mL-1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
crystallin, mu
Introduction
CRYM (Crystallin Mu) is a Protein Coding gene. Diseases associated with CRYM include Deafness, Autosomal Dominant 40 and Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna. Among its related pathways are Viral mRNA Translation and Metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and NADP binding.
Entrez Gene ID
1428
UniProt ID
Q14894
Alternative Names
Crystallin Mu; Thiomorpholine-Carboxylate Dehydrogenase; THBP; NADP-Regulated Thyroid-Hormone Binding Protein; NADP-Regulated Thyroid-Hormone-Binding Protein; Ketimine Reductase Mu-Crystallin;
Function
Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors.
Biological Process
Lysine catabolic process Source: Reactome
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Sensory perception of sound Source: UniProtKB
Thyroid hormone metabolic process Source: GO_Central
Thyroid hormone transport Source: UniProtKB
Cellular Location
Cytoplasm
Involvement in disease
Deafness, autosomal dominant, 40 (DFNA40):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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