CRYM

Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]
Full Name
crystallin, mu
Function
Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors.
Biological Process
Lysine catabolic process Source: Reactome
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Sensory perception of sound Source: UniProtKB
Thyroid hormone metabolic process Source: GO_Central
Thyroid hormone transport Source: UniProtKB
Cellular Location
Cytoplasm
Involvement in disease
Deafness, autosomal dominant, 40 (DFNA40):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
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Anti-CRYM antibodies

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Mouse Anti-CRYM Recombinant Antibody (1G7) (CBMAB-C4194-LY)

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Target: CRYM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1G7
Application*: E, WB
Datasheet SDS

Mouse Anti-CRYM Recombinant Antibody (CBFYM-1026) (CBMAB-M1178-FY)

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Target: CRYM
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBFYM-1026
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CRYM Recombinant Antibody (CBFYC-2257) (V2LY-1206-LY1337)

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Target: CRYM
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBFYC-2257
Application*: F, IF, IH, WB
Datasheet SDS

Mouse Anti-CRYM Recombinant Antibody (CBFYM-1025) (V2LY-1206-LY1334)

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Target: CRYM
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-1025
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CRYM Recombinant Antibody (6B3) (V2LY-1206-LY1333)

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Target: CRYM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6B3
Application*: E, P, WB, IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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