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Human Anti-CSF2RA Recombinant Antibody (CBXC-0747) (CBMAB-C1861-CQ)

This product is a recombinant human antibody that recognizes CSF2RA. The antibody CBXC-0747 can be used for immunoassay techniques such as: FC.
See all CSF2RA antibodies

Summary

Host Animal
Human
Specificity
Human
Clone
CBXC-0747
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Buffer containing stabilizer
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Colony Stimulating Factor 2 Receptor Alpha Subunit
Introduction
CSF2RA (Colony Stimulating Factor 2 Receptor Alpha Subunit) is a Protein Coding gene. Diseases associated with CSF2RA include Surfactant Metabolism Dysfunction, Pulmonary, 4 and Hereditary Pulmonary Alveolar Proteinosis. Among its related pathways are RET signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include receptor activity and cytokine receptor activity. An important paralog of this gene is IL3RA.
Entrez Gene ID
1438
UniProt ID
P15509
Alternative Names
Colony Stimulating Factor 2 Receptor Alpha Subunit; Colony Stimulating Factor 2 Receptor, Alpha, Low-Affinity (Granulocyte-Macrophage); Alpha-GM-CSF Receptor; GM-CSF-R-Alpha; CD116 Antigen; GMCSFR-Alpha; GMR-Alpha; CDw116; CSF2RY; CSF2R; Granulocyte-Macrophage Colony-Stimulating Factor Receptor Subunit Alpha;
Function
Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
Biological Process
Cellular protein metabolic process Source: Reactome
Cytokine-mediated signaling pathway Source: GO_Central
MAPK cascade Source: Reactome
Cellular Location
Cell membrane
Isoform 3&4&6: Secreted
Involvement in disease
Pulmonary surfactant metabolism dysfunction 4 (SMDP4):
A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
Topology
Extracellular: 23-320
Helical: 321-346
Cytoplasmic: 347-400
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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