CSF2RA
CSF2RA (Colony Stimulating Factor 2 Receptor Alpha Subunit) is a Protein Coding gene. Diseases associated with CSF2RA include Surfactant Metabolism Dysfunction, Pulmonary, 4 and Hereditary Pulmonary Alveolar Proteinosis. Among its related pathways are RET signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include receptor activity and cytokine receptor activity. An important paralog of this gene is IL3RA.
Full Name
Colony Stimulating Factor 2 Receptor Alpha Subunit
Function
Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
Biological Process
Cellular protein metabolic process Source: Reactome
Cytokine-mediated signaling pathway Source: GO_Central
MAPK cascade Source: Reactome
Cytokine-mediated signaling pathway Source: GO_Central
MAPK cascade Source: Reactome
Cellular Location
Cell membrane
Isoform 3&4&6: Secreted
Isoform 3&4&6: Secreted
Involvement in disease
Pulmonary surfactant metabolism dysfunction 4 (SMDP4):
A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
Topology
Extracellular: 23-320
Helical: 321-346
Cytoplasmic: 347-400
Helical: 321-346
Cytoplasmic: 347-400
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Anti-CSF2RA antibodies
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CompareTarget: CSF2RA
Sensitivity: 0.0054 ng/mL
Detection Range: 0.01-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: CSF2RA
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-320
Tag: His Tag
Target: CSF2RA
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-320
Tag: hFc Tag
Target: CSF2RA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT4812
Application*: IH
Target: CSF2RA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG840
Application*: E
Target: CSF2RA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: AP1734
Application*: F
Target: CSF2RA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 14L270
Application*: E, F
Target: CSF2RA
Host: Human
Antibody Isotype: IgG4
Specificity: Human
Clone: CBWJC-3183
Application*: F
Target: CSF2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3182
Application*: E
Target: CSF2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-2070
Application*: F, WB
Target: CSF2RA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBXC-0584
Application*: WB, IP, IF, F
Target: CSF2RA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-2563
Application*: WB, IP, IF, E
Target: CSF2RA
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0747
Application*: F
Target: CSF2RA
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBYY-C2892
Application*: WB, IP, IF, E
Target: CSF2RA
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYH-3359
Application*: F, N, IF
Target: CSF2RA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBLG1-3130
Application*: WB, IP
Target: CSF2RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: G1417
Application*: WB
Target: CSF2RA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2G5
Application*: E, WB
Target: CSF2RA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYH-0105
Application*: WB, IP, IF, F
Target: CSF2RA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYH-0106
Application*: WB, IP, IF, F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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