Human Recombinant CSF2RA protein, hFc Tag (V2LY-0526-LY4357)

Name: Human Recombinant CSF2RA protein, hFc Tag
SKU: V2LY-0526-LY4357
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant CSF2RA protein, hFc Tag consist of Amino Acid: 1-320 and predicts a molecular mass of 61.2 kDa.

Molecule Mass

61.2 kDa

Verified

HPLC

Sequence

Amino Acid: 1-320

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥90% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Colony Stimulating Factor 2 Receptor Alpha Subunit

Function

Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.

Biological Process

Cellular protein metabolic process Source: Reactome
Cytokine-mediated signaling pathway Source: GO_Central
MAPK cascade Source: Reactome

Cellular Location

Cell membrane
Isoform 3&4&6: Secreted

Involvement in disease

Pulmonary surfactant metabolism dysfunction 4 (SMDP4):
A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.

Topology

Extracellular: 23-320
Helical: 321-346
Cytoplasmic: 347-400

Xiao, Y., Uh, K., Negrón-Pérez, V. M., Haines, H., Lee, K., & Hansen, P. J. (2021). Regulation of gene expression in the bovine blastocyst by colony-stimulating factor 2 is disrupted by CRISPR/Cas9-mediated deletion of CSF2RA. Biology of Reproduction, 104(5), 995-1007.

Xiao, Y., Uh, K., Negrón-Pérez, V. M., Haines, H., Lee, K., & Hansen, P. J. (2021). Regulation of gene expression in the bovine blastocyst by CSF2 is disrupted by CRISPR/Cas9-mediated deletion of CSF2RA. Biology of Reproduction.

Sinkey, R. G., Guzeloglu-Kayisli, O., Arlier, S., Guo, X., Semerci, N., Moore, R., ... & Lockwood, C. J. (2020). Thrombin-induced decidual colony-stimulating factor-2 promotes abruption-related preterm birth by weakening fetal membranes. The American journal of pathology, 190(2), 388-399.

Huang, R., Cao, Y., Li, H., Hu, Z., Zhang, H., Zhang, L., ... & Li, X. (2020). miR-532-3p-CSF2RA axis as a key regulator of vulnerable atherosclerotic plaque formation. Canadian Journal of Cardiology, 36(11), 1782-1794.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CSF2RA protein, His Tag (CAT#: V2LY-0526-LY4358)

Human CSF2RA ELISA Kit (CAT#: V2LY-0626-LY4636)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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