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Rat Anti-CSF2RA Recombinant Antibody (CBFYH-3359) (V2LY-1206-LY1440)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBFYH-3359
Antibody Isotype
IgG2a
Application
FC, Neutralization, IF

Basic Information

Immunogen
Recombinant mouse GM-CSF R alpha, Leu30-Pro327.
Host Species
Rat
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
FC0.25 µg/10^6 cells
IF(ICC)8-25 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Colony Stimulating Factor 2 Receptor Alpha Subunit
Entrez Gene ID
12982
UniProt ID
Q00941
Function
Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
Biological Process
Cellular protein metabolic process Source: Reactome
Cytokine-mediated signaling pathway Source: GO_Central
MAPK cascade Source: Reactome
Cellular Location
Cell membrane
Isoform 3&4&6: Secreted
Involvement in disease
Pulmonary surfactant metabolism dysfunction 4 (SMDP4):
A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
Topology
Extracellular: 23-320
Helical: 321-346
Cytoplasmic: 347-400
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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