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Rat Anti-CSF3R (AA 26-626) Recombinant Antibody (CBFYC-2290) (CBMAB-C2362-FY)

This product is rat antibody that recognizes CSF3R. The antibody CBFYC-2290 can be used for immunoassay techniques such as: Neut.
See all CSF3R antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBFYC-2290
Antibody Isotype
IgG2b
Application
Neut

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, 5% trehalose
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 26-626

Target

Full Name
Colony Stimulating Factor 3 Receptor
Introduction
A patient with CNL carrying a JAK-activating CSF3R mutation had marked clinical improvement after the administration of the JAK1/2 inhibitor ruxolitinib.
Entrez Gene ID
12986
UniProt ID
P40223
Alternative Names
Cd114; Csfgr; G-CSFR; G-CSF-R
Function
Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface.
Biological Process
Amelogenesis Source: Ensembl
Cell adhesion Source: UniProtKB-KW
Cytokine-mediated signaling pathway Source: GO_Central
Defense response Source: ProtInc
Neutrophil chemotaxis Source: Ensembl
Regulation of myeloid cell differentiation Source: Ensembl
Signal transduction Source: ProtInc
Cellular Location
Isoform 2: Secreted; Cell membrane
Involvement in disease
Hereditary neutrophilia (NEUTROPHILIA):
A form of lifelong, persistent neutrophilia, a condition characterized by an increase in the number of neutrophils in the blood.
Neutropenia, severe congenital 7, autosomal recessive (SCN7):
A form of severe congenital neutropenia, a disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.
Topology
Extracellular: 25-627
Helical: 628-650
Cytoplasmic: 651-836
PTM
N-glycosylated.

Chen, X., Wang, B., Pang, A., Yuan, W., Jiang, E., Chu, Y., ... & Han, M. (2021). Colony-stimulating factor 3 receptor (CSF3R) M696T mutation does not impact on clinical outcomes of a Ph+ acute lymphoblastic leukemia patient. Blood Science, 3(03), 87-92.

Kwon, A., Ibrahim, I., Le, T., Jaso, J., Weinberg, O., Fuda, F., & Chen, W. (2021). Colony-stimulating factor 3 receptor gene (CSF3R) T618I mutated chronic myelomonocytic leukemia: A proliferative subtype with a distinct mutational profile. American Journal of Clinical Pathology, 156(Supplement_1), S95-S95.

Saunders, A. S., Bender, D. E., Ray, A. L., Wu, X., & Morris, K. T. (2021). Colony-stimulating factor 3 signaling in colon and rectal cancers: Immune response and CMS classification in TCGA data. Plos one, 16(2), e0247233.

Tarlock, K., Alonzo, T., Wang, Y. C., Gerbing, R. B., Ries, R. E., Hylkema, T., ... & Meshinchi, S. (2020). Prognostic impact of CSF3R mutations in favorable risk childhood acute myeloid leukemia. Blood, 135(18), 1603-1606.

Yilmaz Karapinar, D., Akinci, B., Şahin Yaşar, A., Hekimci Özdemir, H., Önder Siviş, Z., Onay, H., & Özkinay, F. (2019). Congenital neutropenia patient with hypomorphic biallelic CSF3R mutation responding to GCSF. Journal of Pediatric Hematology/Oncology, 41(3), e190-e192.

Zhang, H., Coblentz, C., Watanabe-Smith, K., Means, S., Means, J., Maxson, J. E., & Tyner, J. W. (2018). Gain-of-function mutations in granulocyte colony–stimulating factor receptor (CSF3R) reveal distinct mechanisms of CSF3R activation. Journal of Biological Chemistry, 293(19), 7387-7396.

Qiu, Y., Zhang, Y., Hu, N., & Dong, F. (2017). A truncated granulocyte colony-stimulating factor receptor (G-CSFR) inhibits apoptosis induced by neutrophil elastase G185R mutant: implication for understanding CSF3R gene mutations in severe congenital neutropenia. Journal of Biological Chemistry, 292(8), 3496-3505.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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