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CSF3R

CSF1R (Colony Stimulating Factor 1 Receptor) is a Protein Coding gene. Diseases associated with CSF1R include Leukoencephalopathy, Hereditary Diffuse, With Spheroids and Pigmented Villonodular Synovitis. Among its related pathways are ERK Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is KIT.

Full Name

Colony Stimulating Factor 3 Receptor

Function

Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface.

Biological Process

Amelogenesis Source: Ensembl
Cell adhesion Source: UniProtKB-KW
Cytokine-mediated signaling pathway Source: GO_Central
Defense response Source: ProtInc
Neutrophil chemotaxis Source: Ensembl
Regulation of myeloid cell differentiation Source: Ensembl
Signal transduction Source: ProtInc

Cellular Location

Isoform 2: Secreted; Cell membrane

Involvement in disease

Hereditary neutrophilia (NEUTROPHILIA):
A form of lifelong, persistent neutrophilia, a condition characterized by an increase in the number of neutrophils in the blood.
Neutropenia, severe congenital 7, autosomal recessive (SCN7):
A form of severe congenital neutropenia, a disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.

Topology

Extracellular: 25-627
Helical: 628-650
Cytoplasmic: 651-836

PTM

N-glycosylated.

Anti-CSF3R antibodies

Mouse Anti-CSF3R Recombinant Antibody (LMM741) (CBMAB-C5633-CQ)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: LMM741

Application*: F

Mouse Anti-CSF3R Recombinant Antibody (S1390) (CBMAB-G1484-LY)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Mouse, Human

Clone: S1390

Application*: WB

Mouse Anti-CSF3R Recombinant Antibody (CBFYH-0113) (CBMAB-H0974-FY)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYH-0113

Application*: WB

Rat Anti-CSF3R Recombinant Antibody (CBYY-C2167) (CBMAB-C3605-YY)

SDS

Target: CSF3R

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBYY-C2167

Application*: F

Rat Anti-CSF3R (AA 26-626) Recombinant Antibody (CBFYC-2290) (CBMAB-C2362-FY)

SDS

Target: CSF3R

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: CBFYC-2290

Application*: N

Mouse Anti-CSF3R Recombinant Antibody (CBFYH-0114) (CBMAB-H0975-FY)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYH-0114

Application*: F

Mouse Anti-CSF3R Monoclonal Antibody (CBFYR0186) (CBMAB-R0186-FY)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYR0186

Application*: WB

Mouse Anti-CSF3R Recombinant Antibody (38660) (CBMAB-G0077-LY)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 38660

Application*: WB

Rabbit Anti-CSF3R Recombinant Antibody (48) (CBMAB-G0079-LY)

SDS

Target: CSF3R

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 48

Application*: F

Mouse Anti-CSF3R Monoclonal Antibody (CBFYR0191) (CBMAB-R0191-FY)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYR0191

Application*: WB, IP

Mouse Anti-CSF3R Monoclonal Antibody (CBFYR0190) (CBMAB-R0190-FY)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYR0190

Application*: WB

Mouse Anti-CSF3R Monoclonal Antibody (CBFYR0189) (CBMAB-R0189-FY)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYR0189

Application*: WB

Mouse Anti-CSF3R Monoclonal Antibody (CBFYR0188) (CBMAB-R0188-FY)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYR0188

Application*: WB

Mouse Anti-CSF3R Recombinant Antibody (CBLG1-011) (CBMAB-G0085-LY)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-011

Application*: F

Mouse Anti-CSF3R Recombinant Antibody (10K224) (CBMAB-G1465-LY)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 10K224

Application*: E, DB, WB

Mouse Anti-CSF3R Recombinant Antibody (11C109) (CBMAB-G1466-LY)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 11C109

Application*: E, F

Mouse Anti-CSF3R Recombinant Antibody (14L451) (CBMAB-G1467-LY)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 14L451

Application*: F

Mouse Anti-CSF3R Recombinant Antibody (2D9G1E3) (CBMAB-G1468-LY)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2D9G1E3

Application*: E, ED

Mouse Anti-CSF3R Recombinant Antibody (3) (CBMAB-G1469-LY)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 3

Application*: IF/IC

Mouse Anti-CSF3R Recombinant Antibody (3H132) (CBMAB-G1470-LY)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 3H132

Application*: E, WB

Mouse Anti-CSF3R Recombinant Antibody (3H134) (CBMAB-G1471-LY)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3H134

Application*: E, WB

Mouse Anti-CSF3R Recombinant Antibody (3H137) (CBMAB-G1474-LY)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 3H137

Application*: E, WB

Mouse Anti-CSF3R Recombinant Antibody (8F19) (CBMAB-G1475-LY)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 8F19

Application*: F

Mouse Anti-CSF3R Recombinant Antibody (8H165) (CBMAB-G1476-LY)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 8H165

Application*: E

Mouse Anti-CSF3R Recombinant Antibody (S-1268) (CBMAB-G1482-LY)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: S-1268

Application*: WB

Mouse Anti-CSF3R Recombinant Antibody (S-1284) (CBMAB-G1483-LY)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: S-1284

Application*: IC/IF, P, WB

Mouse Anti-CSF3R Recombinant Antibody (S-425) (CBMAB-G1485-LY)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: S-425

Application*: WB

Mouse Anti-CSF3R Recombinant Antibody (CBLG1-378) (CBMAB-G1486-LY)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-378

Application*: IC/IF, IF

Mouse Anti-CSF3R Recombinant Antibody (S-1390) (CBMAB-R0486-CN)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: S-1390

Application*: E, WB

Mouse Anti-CSF3R Monoclonal Antibody (CBFYR0187) (CBMAB-R0187-FY)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYR0187

Application*: WB

Mouse Anti-CSF3R Recombinant Antibody (38643) (CBMAB-G0076-LY)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 38643

Application*: F

Mouse Anti-CSF3R Recombinant Antibody (6) (CBMAB-G0080-LY)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 6

Application*: IF/IC

Rat Anti-CSF3R Recombinant Antibody (680206) (CBMAB-G0081-LY)

SDS

Target: CSF3R

Host: Rat

Antibody Isotype: IgG

Specificity: Mouse

Clone: 680206

Application*: N

Rat Anti-CSF3R Recombinant Antibody (723806) (CBMAB-G0082-LY)

SDS

Target: CSF3R

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: 723806

Application*: F

Mouse Anti-CSF3R Recombinant Antibody (LMM775) (CBMAB-G0083-LY)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: LMM775

Application*: F

Mouse Anti-CSF3R Recombinant Antibody (CBCNC-402) (CBMAB-C2942-CN)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBCNC-402

Application*: E, IP, WB

Mouse Anti-CSF3R Recombinant Antibody (CBCNC-403) (CBMAB-C2943-CN)

SDS

Target: CSF3R

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBCNC-403

Application*: E, IP, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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