Human Recombinant CSF3R protein, hFc Tag (V2LY-0526-LY3389)

Name: Human Recombinant CSF3R protein, hFc Tag
SKU: V2LY-0526-LY3389
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant CSF3R protein, hFc Tag consist of Amino Acid: 1-621 and predicts a molecular mass of 93.3 kDa.

Molecule Mass

93.3 kDa

Sequence

Amino Acid: 1-621

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Colony Stimulating Factor 3 Receptor

Function

Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface.

Biological Process

Amelogenesis Source: Ensembl
Cell adhesion Source: UniProtKB-KW
Cytokine-mediated signaling pathway Source: GO_Central
Defense response Source: ProtInc
Neutrophil chemotaxis Source: Ensembl
Regulation of myeloid cell differentiation Source: Ensembl
Signal transduction Source: ProtInc

Cellular Location

Isoform 2: Secreted; Cell membrane

Involvement in disease

Hereditary neutrophilia (NEUTROPHILIA):
A form of lifelong, persistent neutrophilia, a condition characterized by an increase in the number of neutrophils in the blood.
Neutropenia, severe congenital 7, autosomal recessive (SCN7):
A form of severe congenital neutropenia, a disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.

Topology

Extracellular: 25-627
Helical: 628-650
Cytoplasmic: 651-836

PTM

N-glycosylated.

Chen, X., Wang, B., Pang, A., Yuan, W., Jiang, E., Chu, Y., ... & Han, M. (2021). Colony-stimulating factor 3 receptor (CSF3R) M696T mutation does not impact on clinical outcomes of a Ph+ acute lymphoblastic leukemia patient. Blood Science, 3(03), 87-92.

Kwon, A., Ibrahim, I., Le, T., Jaso, J., Weinberg, O., Fuda, F., & Chen, W. (2021). Colony-stimulating factor 3 receptor gene (CSF3R) T618I mutated chronic myelomonocytic leukemia: A proliferative subtype with a distinct mutational profile. American Journal of Clinical Pathology, 156(Supplement_1), S95-S95.

Saunders, A. S., Bender, D. E., Ray, A. L., Wu, X., & Morris, K. T. (2021). Colony-stimulating factor 3 signaling in colon and rectal cancers: Immune response and CMS classification in TCGA data. Plos one, 16(2), e0247233.

Tarlock, K., Alonzo, T., Wang, Y. C., Gerbing, R. B., Ries, R. E., Hylkema, T., ... & Meshinchi, S. (2020). Prognostic impact of CSF3R mutations in favorable risk childhood acute myeloid leukemia. Blood, 135(18), 1603-1606.

Yilmaz Karapinar, D., Akinci, B., Şahin Yaşar, A., Hekimci Özdemir, H., Önder Siviş, Z., Onay, H., & Özkinay, F. (2019). Congenital neutropenia patient with hypomorphic biallelic CSF3R mutation responding to GCSF. Journal of Pediatric Hematology/Oncology, 41(3), e190-e192.

Zhang, H., Coblentz, C., Watanabe-Smith, K., Means, S., Means, J., Maxson, J. E., & Tyner, J. W. (2018). Gain-of-function mutations in granulocyte colony–stimulating factor receptor (CSF3R) reveal distinct mechanisms of CSF3R activation. Journal of Biological Chemistry, 293(19), 7387-7396.

Qiu, Y., Zhang, Y., Hu, N., & Dong, F. (2017). A truncated granulocyte colony-stimulating factor receptor (G-CSFR) inhibits apoptosis induced by neutrophil elastase G185R mutant: implication for understanding CSF3R gene mutations in severe congenital neutropenia. Journal of Biological Chemistry, 292(8), 3496-3505.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CSF3R protein, His Tag (CAT#: V2LY-0526-LY3390)

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Isotype control

For research use only. Not intended for any clinical use.

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