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Mouse Anti-CSNK1A1 Recombinant Antibody (16C22) (CBMAB-C0407-LY)

This product is antibody recognizes CSNK1A1. The antibody 16C22 immunoassay techniques such as: ELISA, WB.
See all CSNK1A1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
16C22
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein corresponding to aa1-337 from human Casein Kinase 1 alpha expressed in E. coli
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
10% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Casein Kinase 1 Alpha 1
Introduction
CSNK1A1 (Casein Kinase 1 Alpha 1) is a Protein Coding gene. Among its related pathways are S33 mutants of beta-catenin arent phosphorylated and NFAT and Cardiac Hypertrophy. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.
An important paralog of this gene is CSNK1A1L.
Entrez Gene ID
1452
UniProt ID
P48729
Alternative Names
Casein Kinase 1 Alpha 1; Clock Regulator Kinase; EC 2.7.11.1; CKI-Alpha; CK1; Epididymis Secretory Sperm Binding Protein Li 77p; Casein Kinase I Isoform Alpha; Down-Regulated In Lung Cancer;
Function
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108).

May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).
Biological Process
Beta-catenin destruction complex assembly Source: Reactome
Beta-catenin destruction complex disassembly Source: Reactome
Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Cell surface receptor signaling pathway Source: ProtInc
Golgi organization Source: ParkinsonsUK-UCL
Intermediate filament cytoskeleton organization Source: UniProtKB
Negative regulation of canonical Wnt signaling pathway Source: WormBase
Peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: FlyBase
Protein phosphorylation Source: UniProtKB
Regulation of GTP binding Source: ParkinsonsUK-UCL
Signal transduction Source: ProtInc
Wnt signaling pathway Source: Reactome
Cellular Location
Cytoplasm; Nucleus speckle; Centrosome; Cilium basal body; Kinetochore. Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton (PubMed:23902688).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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