CSNK1A1

CSNK1A1 (Casein Kinase 1 Alpha 1) is a Protein Coding gene. Among its related pathways are S33 mutants of beta-catenin arent phosphorylated and NFAT and Cardiac Hypertrophy. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1A1L.

Full Name

Casein Kinase 1 Alpha 1

Function

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108).

May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).

Biological Process

Beta-catenin destruction complex assembly Source: Reactome
Beta-catenin destruction complex disassembly Source: Reactome
Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Cell surface receptor signaling pathway Source: ProtInc
Golgi organization Source: ParkinsonsUK-UCL
Intermediate filament cytoskeleton organization Source: UniProtKB
Negative regulation of canonical Wnt signaling pathway Source: WormBase
Peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: FlyBase
Protein phosphorylation Source: UniProtKB
Regulation of GTP binding Source: ParkinsonsUK-UCL
Signal transduction Source: ProtInc
Wnt signaling pathway Source: Reactome

Cellular Location

Cytoplasm; Nucleus speckle; Centrosome; Cilium basal body; Kinetochore. Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton (PubMed:23902688).