CSNK1A1

CSNK1A1 (Casein Kinase 1 Alpha 1) is a Protein Coding gene. Among its related pathways are S33 mutants of beta-catenin arent phosphorylated and NFAT and Cardiac Hypertrophy. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1A1L.
Full Name
Casein Kinase 1 Alpha 1
Function
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108).

May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).
Biological Process
Beta-catenin destruction complex assembly Source: Reactome
Beta-catenin destruction complex disassembly Source: Reactome
Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Cell surface receptor signaling pathway Source: ProtInc
Golgi organization Source: ParkinsonsUK-UCL
Intermediate filament cytoskeleton organization Source: UniProtKB
Negative regulation of canonical Wnt signaling pathway Source: WormBase
Peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: FlyBase
Protein phosphorylation Source: UniProtKB
Regulation of GTP binding Source: ParkinsonsUK-UCL
Signal transduction Source: ProtInc
Wnt signaling pathway Source: Reactome
Cellular Location
Cytoplasm; Nucleus speckle; Centrosome; Cilium basal body; Kinetochore. Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton (PubMed:23902688).
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Anti-CSNK1A1 antibodies

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Mouse Anti-CSNK1A1 Recombinant Antibody (CBT257) (V2LY-0625-LY3660)

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Target: CSNK1A1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT257
Application*: WB, P, IF, E
Datasheet SDS

Rabbit Anti-CSNK1A1 Recombinant Antibody (C2410) (V2LY-0125-LY6)

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Target: CSNK1A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: C2410
Application*: WB, IP, IF, F
Datasheet SDS

Mouse Anti-CSNK1A1 Recombinant Antibody (CBFYC-0422) (V2LY-0125-LY5)

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Target: CSNK1A1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-0422
Application*: WB, E, IF
Datasheet SDS

Mouse Anti-CSNK1A1 Recombinant Antibody (CBLC-LY-017) (V2LY-0125-LY4)

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Target: CSNK1A1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBLC-LY-017
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-CSNK1A1 Recombinant Antibody (C5778) (V2LY-0125-LY3)

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Target: CSNK1A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: C5778
Application*: WB, IP, IF, F, P
Datasheet SDS

Mouse Anti-CSNK1A1 Recombinant Antibody (C0407) (V2LY-0125-LY2)

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Target: CSNK1A1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: C0407
Application*: WB, IP, IF, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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