Rabbit Anti-CSNK1A1 Recombinant Antibody (C5778) (V2LY-0125-LY3)

Name: Rabbit Anti-CSNK1A1 Recombinant Antibody (C5778)
SKU: V2LY-0125-LY3
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse, Rat

Clone

C5778

Antibody Isotype

IgG

Application

WB, IP, IF, FC, IHC-P

Basic Information

Immunogen

Recombinant protein within human CSNK1A1 aa 1-337.

Host Species

Rabbit

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

Application	Note
FC	1:1,000
IF(ICC)	1:500
IHC-P	1:1,000
WB	1:2,000
IP	1-2 μg per sample

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

BSA, Glycerol & PBS

Preservative

Sodium Azide

Concentration

1 mg/mL

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Casein Kinase 1 Alpha 1

Entrez Gene ID

1452

UniProt ID

P48729

Function

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108).

May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).

Biological Process

Beta-catenin destruction complex assembly Source: Reactome
Beta-catenin destruction complex disassembly Source: Reactome
Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Cell surface receptor signaling pathway Source: ProtInc
Golgi organization Source: ParkinsonsUK-UCL
Intermediate filament cytoskeleton organization Source: UniProtKB
Negative regulation of canonical Wnt signaling pathway Source: WormBase
Peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: FlyBase
Protein phosphorylation Source: UniProtKB
Regulation of GTP binding Source: ParkinsonsUK-UCL
Signal transduction Source: ProtInc
Wnt signaling pathway Source: Reactome

Cellular Location

Cytoplasm; Nucleus speckle; Centrosome; Cilium basal body; Kinetochore. Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton (PubMed:23902688).

More Infomation

References

Liu, G., Li, H., Zhang, W., Yu, J., Zhang, X., Wu, R., ... & Yu, R. (2021). Csnk1a1 inhibition modulates the inflammatory secretome and enhances response to radiotherapy in glioma. Journal of cellular and molecular medicine, 25(15), 7395-7406.

Xu, W., Huang, Z., Gan, Y., Chen, R., Huang, Y., Xue, B., ... & Zhang, S. (2020). Casein kinase 1α inhibits p53 downstream of MDM2‑mediated autophagy and apoptosis in acute myeloid leukemia. Oncology reports, 44(5), 1895-1904.

Huang, Q., Chen, L., Schonbrunn, E., & Chen, J. (2020). MDMX inhibits casein kinase 1α activity and stimulates Wnt signaling. The EMBO journal, 39(14), e104410.

Ebert, B. L., & Krönke, J. (2018). Inhibition of casein kinase 1 alpha in acute myeloid leukemia. New England journal of medicine, 379(19), 1873-1874.

Jiang, S., Zhang, M., Sun, J., & Yang, X. (2018). Casein kinase 1α: biological mechanisms and theranostic potential. Cell Communication and Signaling, 16(1), 1-24.

Ghoul, E., Chalhoub, E., & Abdel-Samad, R. (2018). PO-150 Modulation of the expression of casein kinase i isoform alpha in the initiation and progression of prostate cancer. ESMO Open, 3, A285.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Mouse Anti-CSNK1A1 Recombinant Antibody (CBLC-LY-017)

Rabbit Anti-CSNK1A1 Recombinant Antibody (C2410)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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Second antibody and isotype control

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