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Mouse Anti-CSNK1A1 Recombinant Antibody (C0407) (V2LY-0125-LY2)


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Published Data
V2LY-0125-LY2-1
Mouse Anti-CSNK1A1 Recombinant Antibody (C0407) (V2LY-0125-LY2) in WB
Western blot of AXIN1, β-TrCP and HOXB3 CO-IP with CKIα in WNT3A-treated LNCaP-AI cells that harvested at different time points as indicated. Inputs: Western blot of CKIα, HOXB3, AXIN1 and β-TrCP in the same lysates as above. ...View More
Zhu, S., Yang, Z., Zhang, Z., Zhang, H., Li, S., Wu, T., ... & Niu, Y. (2023). HOXB3 drives WNT-activation associated progression in castration-resistant prostate cancer. Cell death & disease, 14(3), 215. Distributed under Open Access license CC BY 4.0, without modification.
V2LY-0125-LY2-2
Mouse Anti-CSNK1A1 Recombinant Antibody (C0407) (V2LY-0125-LY2) in WB
Western analyses of CK1a levels in C3H10T1/2 cells transfectedwithmyc-Taz and CK1a siRNA. ...View More
Tang, C., Wang, J., Yao, M., Ji, X., Shi, W., Xu, C., ... & Wu, X. (2023). Hippo signaling activates hedgehog signaling by Taz-driven Gli3 processing. Cell Regeneration, 12(1), 3. Distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
V2LY-0125-LY2-3
Mouse Anti-CSNK1A1 Recombinant Antibody (C0407) (V2LY-0125-LY2) in WB
Detection of CK1 and TOM40 expression at protein levels with Western blot. ...View More
Huang, K., Jia, Z., Li, H., Peng, Y., Chen, X., Luo, N., ... & Yang, G. (2022). Proto-oncogene FAM83A contributes to casein kinase 1-mediated mitochondrial maintenance and white adipocyte differentiation. Journal of Biological Chemistry, 298(10). Distributed under Open Access license CC BY 4.0, without modification.
V2LY-0125-LY2-4
Mouse Anti-CSNK1A1 Recombinant Antibody (C0407) (V2LY-0125-LY2) in WB
HeLa cells were infected with adenovirus expressing shRNA for PLK1, CSNK1A1, NEK7 or SCR. ...View More
Fujimoto, M., Takii, R., Matsumoto, M., Okada, M., Nakayama, K. I., Nakato, R., ... & Nakai, A. (2022). HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis. Nature communications, 13(1), 4355. Distributed under Open Access license CC BY 4.0, without modification.
V2LY-0125-LY2-5
Mouse Anti-CSNK1A1 Recombinant Antibody (C0407) (V2LY-0125-LY2) in IP
NLRP3 was ectopically expressed with HA-CSNK1A1 in 293T. HA-CSNK1A1 immunoprecipitates were analyzed for NLRP3. ...View More
Niu, T., De Rosny, C., Chautard, S., Rey, A., Patoli, D., Groslambert, M., ... & Py, B. F. (2021). NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly. Nature communications, 12(1), 5862. Distributed under Open Access license CC BY 4.0, without modification.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
C0407
Antibody Isotype
IgG2a, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 281-337 mapping at the C-terminus of human casein kinase Iα.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Gelatin & PBS
Preservative
Sodium Azide
Concentration
0.2 mg/mL
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Casein Kinase 1 Alpha 1
Entrez Gene ID
1452
UniProt ID
P48729
Function
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108).

May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).
Biological Process
Beta-catenin destruction complex assembly Source: Reactome
Beta-catenin destruction complex disassembly Source: Reactome
Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Cell surface receptor signaling pathway Source: ProtInc
Golgi organization Source: ParkinsonsUK-UCL
Intermediate filament cytoskeleton organization Source: UniProtKB
Negative regulation of canonical Wnt signaling pathway Source: WormBase
Peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: FlyBase
Protein phosphorylation Source: UniProtKB
Regulation of GTP binding Source: ParkinsonsUK-UCL
Signal transduction Source: ProtInc
Wnt signaling pathway Source: Reactome
Cellular Location
Cytoplasm; Nucleus speckle; Centrosome; Cilium basal body; Kinetochore. Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton (PubMed:23902688).
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For research use only. Not intended for any clinical use.

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