Mouse Anti-CST7 Recombinant Antibody (CBCNC-431) (CBMAB-C3013-CN)

This product is a Mouse antibody that recognizes CST7. The antibody CBCNC-431 can be used for immunoassay techniques such as: ELISA.
See all CST7 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBCNC-431

Antibody Isotype

IgG1

Application

ELISA

Basic Information

Immunogen

Recombinant human CST7 protein

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name

Cystatin F

Introduction

CST7 (Cystatin F) is a Protein Coding gene. Diseases associated with CST7 include Aicardi-Goutieres Syndrome. Gene Ontology (GO) annotations related to this gene include endopeptidase inhibitor activity and cysteine-type endopeptidase inhibitor activity.

Entrez Gene ID

8530

UniProt ID

O76096

Alternative Names

Cystatin F; Leukocystatin; Cystatin-Like Metastasis-Associated Protein; Cystatin-7; CMAP; Cystatin F (Leukocystatin); Cystatin-F;

Function

Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system.

Biological Process

Immune response Source: ProtInc
Inhibition of cysteine-type endopeptidase activity Source: GO_Central
Negative regulation of microglial cell activation Source: GO_Central
Negative regulation of peptidase activity Source: ARUK-UCL
Positive regulation of myelination Source: GO_Central

Cellular Location

Secreted; Cytoplasm

References

Sawyer, A. J., Garand, M., Chaussabel, D., & Feng, C. G. (2021). Transcriptomic Profiling Identifies Neutrophil-Specific Upregulation of Cystatin F as a Marker of Acute Inflammation in Humans. Frontiers in immunology, 12.

Senjor, E., Perišić Nanut, M., Breznik, B., Mitrović, A., Mlakar, J., Rotter, A., ... & Kos, J. (2021). Cystatin F acts as a mediator of immune suppression in glioblastoma. Cellular Oncology, 44(5), 1051-1063.

Yang, C., Yu, T., Liu, Z., Ye, X., Liao, X., Wang, X., ... & Peng, T. (2019). Cystatin F as a key family 2 cystatin subunit and prognostic biomarker for early‑stage pancreatic ductal adenocarcinoma. Oncology reports, 42(1), 79-90.

Dautović, E., Nanut, M. P., Softić, A., & Kos, J. (2018). The transcription factor C/EBP α controls the role of cystatin F during the differentiation of monocytes to macrophages. European Journal of Cell Biology, 97(7), 463-473.

Kos, J., Nanut, M. P., Prunk, M., Sabotič, J., Dautović, E., & Jewett, A. (2018). Cystatin F as a regulator of immune cell cytotoxicity. Cancer Immunology, Immunotherapy, 67(12), 1931-1938.

Nuvolone, M., Schmid, N., Miele, G., Sorce, S., Moos, R., Schori, C., ... & Aguzzi, A. (2017). Cystatin F is a biomarker of prion pathogenesis in mice. PLoS One, 12(2), e0171923.

Perišić Nanut, M., Sabotič, J., Švajger, U., Jewett, A., & Kos, J. (2017). Cystatin F affects natural killer cell cytotoxicity. Frontiers in immunology, 8, 1459.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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