Sign in or Register   Sign in or Register
  |  

Mouse Anti-CTHRC1 (AA 32-141) Recombinant Antibody (CBFYC-2386) (CBMAB-C2459-FY)

This product is mouse antibody that recognizes CTHRC1. The antibody CBFYC-2386 can be used for immunoassay techniques such as: ELISA, IHC-P, WB.
See all CTHRC1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-2386
Antibody Isotype
IgG2a, k
Application
ELISA, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 32-141

Target

Full Name
collagen triple helix repeat containing 1
Introduction
CTHRC1 (Collagen Triple Helix Repeat Containing 1) is a Protein Coding gene. Diseases associated with CTHRC1 include Barrett Esophagus and Adenocarcinoma. Among its related pathways are Noncanonical Wnt signaling pathway and Wnt signaling network. Gene Ontology (GO) annotations related to this gene include frizzled binding and Wnt-protein binding.
Entrez Gene ID
115908
UniProt ID
Q96CG8
Alternative Names
Collagen Triple Helix Repeat Containing 1; Protein NMTC1
Function
May act as a negative regulator of collagen matrix deposition.
Biological Process
Cell migration Source: Ensembl
Cochlea morphogenesis Source: Ensembl
Establishment of planar polarity involved in neural tube closure Source: Ensembl
Inner ear receptor cell stereocilium organization Source: Ensembl
Negative regulation of canonical Wnt signaling pathway Source: Ensembl
Ossification involved in bone remodeling Source: Ensembl
Positive regulation of osteoblast differentiation Source: Ensembl
Positive regulation of osteoblast proliferation Source: Ensembl
Positive regulation of protein binding Source: Ensembl
Wnt signaling pathway, planar cell polarity pathway Source: Ensembl
Cellular Location
Extracellular matrix
Involvement in disease
Barrett esophagus (BE):
A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes.
PTM
N-glycosylated.

Myngbay, A., Manarbek, L., Ludbrook, S., & Kunz, J. (2021). The role of collagen triple helix repeat-containing 1 protein (CTHRC1) in rheumatoid arthritis. International Journal of Molecular Sciences, 22(5), 2426.

Hu, T., Liu, Y., Tan, L., Huang, J., Yu, J., Wu, Y., ... & Xiang, Y. (2021). Value of serum collagen triple helix repeat containing-1 (CTHRC1) and 14-3-3η protein compared to anti-CCP antibodies and anti-MCV antibodies in the diagnosis of rheumatoid arthritis. British Journal of Biomedical Science, 78(2), 67-71.

Ruiz-Villalba, A., Romero, J. P., Hernández, S. C., Vilas-Zornoza, A., Fortelny, N., Castro-Labrador, L., ... & Prósper, F. (2020). Single-cell RNA sequencing analysis reveals a crucial role for CTHRC1 (collagen triple helix repeat containing 1) cardiac fibroblasts after myocardial infarction. Circulation, 142(19), 1831-1847.

Wu, Q., Yang, Q., & Sun, H. (2018). Collagen triple helix repeat containing-1: A novel biomarker associated with disease activity in Systemic lupus erythematosus. Lupus, 27(13), 2076-2085.

Liu, Y., Abulimiti, N., & Wang, C. (2018). Collagen triple helix repeat containing 1 expression in osteosarcoma: a new predictor of prognosis. Annals of Clinical & Laboratory Science, 48(3), 338-344.

Liu, J., Li, W., Liu, S., Zheng, X., Shi, L., Zhang, W., & Yang, H. (2017). Knockdown of Collagen Triple Helix Repeat Containing 1 (CTHRC1) Inhibits Epithelial–Mesenchymal Transition and Cellular Migration in Glioblastoma Cells. Oncology research, 25(2), 225.

Guo, B., Yan, H., Li, L., Yin, K., Ji, F., & Zhang, S. (2017). Collagen triple helix repeat containing 1 (CTHRC1) activates Integrin β3/FAK signaling and promotes metastasis in ovarian cancer. Journal of ovarian research, 10(1), 1-13.

Wang, C., Li, Z., Shao, F., Yang, X., Feng, X., Shi, S., ... & He, J. (2017). High expression of Collagen Triple Helix Repeat Containing 1 (CTHRC1) facilitates progression of oesophageal squamous cell carcinoma through MAPK/MEK/ERK/FRA-1 activation. Journal of Experimental & Clinical Cancer Research, 36(1), 1-14.

Lai, Y. H., Chen, J., Wang, X. P., Wu, Y. Q., Peng, H. T., Lin, X. H., & Wang, W. J. (2017). Collagen triple helix repeat containing-1 negatively regulated by microRNA-30c promotes cell proliferation and metastasis and indicates poor prognosis in breast cancer. Journal of Experimental & Clinical Cancer Research, 36(1), 1-15.

Wu, Q., Yang, Q., & Sun, H. (2017). Role of collagen triple helix repeat containing-1 in tumor and inflammatory diseases. Journal of Cancer Research and Therapeutics, 13(4), 621.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CTHRC1 (AA 32-141) Recombinant Antibody (CBFYC-2386)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare