CTHRC1
CTHRC1 is specifically expressed in vascular calcifications of carotid artery lesions and may contribute to vascular remodeling of injured arteries (Pyagay et al., 2005 [PubMed 15618538]).[supplied by OMIM
Full Name
collagen triple helix repeat containing 1
Function
May act as a negative regulator of collagen matrix deposition.
Biological Process
Cell migration Source: Ensembl
Cochlea morphogenesis Source: Ensembl
Establishment of planar polarity involved in neural tube closure Source: Ensembl
Inner ear receptor cell stereocilium organization Source: Ensembl
Negative regulation of canonical Wnt signaling pathway Source: Ensembl
Ossification involved in bone remodeling Source: Ensembl
Positive regulation of osteoblast differentiation Source: Ensembl
Positive regulation of osteoblast proliferation Source: Ensembl
Positive regulation of protein binding Source: Ensembl
Wnt signaling pathway, planar cell polarity pathway Source: Ensembl
Cochlea morphogenesis Source: Ensembl
Establishment of planar polarity involved in neural tube closure Source: Ensembl
Inner ear receptor cell stereocilium organization Source: Ensembl
Negative regulation of canonical Wnt signaling pathway Source: Ensembl
Ossification involved in bone remodeling Source: Ensembl
Positive regulation of osteoblast differentiation Source: Ensembl
Positive regulation of osteoblast proliferation Source: Ensembl
Positive regulation of protein binding Source: Ensembl
Wnt signaling pathway, planar cell polarity pathway Source: Ensembl
Cellular Location
Extracellular matrix
Involvement in disease
Barrett esophagus (BE):
A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes.
A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes.
PTM
N-glycosylated.
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Anti-CTHRC1 antibodies
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CompareTarget: CTHRC1
Sensitivity: 0.26 ng/mL
Detection Range: 0.5-150 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: CTHRC1
Sensitivity: 1.35 ng/mL
Detection Range: 3-900 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: Cthrc1
Sensitivity: 0.28 ng/mL
Detection Range: 0.5-200 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: CTHRC1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-230
Tag: His Tag
Target: CTHRC1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-245
Tag: His Tag
Target: CTHRC1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-243
Tag: His Tag
Target: CTHRC1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-243
Tag: His Tag
Target: CTHRC1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-243
Tag: His & AVI Tag
Target: CTHRC1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-243
Tag: hFc Tag
Target: CTHRC1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 30-242
Tag: His Tag
Target: CTHRC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-2388
Application*: WB, IP
Target: CTHRC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-2387
Application*: E
Target: CTHRC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2386
Application*: P, WB
Target: CTHRC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 62
Application*: E
Target: CTHRC1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: C4141
Application*: WB, IP, IF, E, P
Target: CTHRC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: 166
Application*: E
Target: CTHRC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: 062
Application*: E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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