CTHRC1

CTHRC1 is specifically expressed in vascular calcifications of carotid artery lesions and may contribute to vascular remodeling of injured arteries (Pyagay et al., 2005 [PubMed 15618538]).[supplied by OMIM

collagen triple helix repeat containing 1

May act as a negative regulator of collagen matrix deposition.

Cell migration Source: Ensembl
Cochlea morphogenesis Source: Ensembl
Establishment of planar polarity involved in neural tube closure Source: Ensembl
Inner ear receptor cell stereocilium organization Source: Ensembl
Negative regulation of canonical Wnt signaling pathway Source: Ensembl
Ossification involved in bone remodeling Source: Ensembl
Positive regulation of osteoblast differentiation Source: Ensembl
Positive regulation of osteoblast proliferation Source: Ensembl
Positive regulation of protein binding Source: Ensembl
Wnt signaling pathway, planar cell polarity pathway Source: Ensembl

Extracellular matrix

Barrett esophagus (BE):
A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes.

N-glycosylated.