Mouse Anti-CTHRC1 Recombinant Antibody (C4141) (V2LY-0125-LY265)

Name: Mouse Anti-CTHRC1 Recombinant Antibody (C4141)
SKU: V2LY-0125-LY265
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-CTHRC1 Recombinant Antibody (C4141) (V2LY-0125-LY265) in IHC

Validation of the expression of DEGs by immunohistochemistry. Immunohistochemical staining of PDL (A) and cementum (B) in tooth roots. ...View More

Mun, S., Kim, S. M., Choi, M. J., & Jang, Y. J. (2022). Transcriptome profile of membrane and extracellular matrix components in ligament-fibroblastic progenitors and cementoblasts differentiated from human periodontal ligament cells. Genes, 13(4), 659. Distributed under Open Access license CC BY 4.0, without modification.

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

C4141

Application

WB, IP, IF, ELISA, IHC-P

Immunogen

Amino acids 32-141 of human CTHRC1.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:100-1:1,000
IP	1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000
IHC-P	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Gelatin & PBS

Preservative

Sodium Azide

Concentration

0.1 mg/mL

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

collagen triple helix repeat containing 1

Entrez Gene ID

115908

UniProt ID

Q96CG8

Function

May act as a negative regulator of collagen matrix deposition.

Biological Process

Cell migration Source: Ensembl
Cochlea morphogenesis Source: Ensembl
Establishment of planar polarity involved in neural tube closure Source: Ensembl
Inner ear receptor cell stereocilium organization Source: Ensembl
Negative regulation of canonical Wnt signaling pathway Source: Ensembl
Ossification involved in bone remodeling Source: Ensembl
Positive regulation of osteoblast differentiation Source: Ensembl
Positive regulation of osteoblast proliferation Source: Ensembl
Positive regulation of protein binding Source: Ensembl
Wnt signaling pathway, planar cell polarity pathway Source: Ensembl

Cellular Location

Extracellular matrix

Involvement in disease

Barrett esophagus (BE):
A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes.

PTM

N-glycosylated.

Myngbay, A., Manarbek, L., Ludbrook, S., & Kunz, J. (2021). The role of collagen triple helix repeat-containing 1 protein (CTHRC1) in rheumatoid arthritis. International Journal of Molecular Sciences, 22(5), 2426.

Hu, T., Liu, Y., Tan, L., Huang, J., Yu, J., Wu, Y., ... & Xiang, Y. (2021). Value of serum collagen triple helix repeat containing-1 (CTHRC1) and 14-3-3η protein compared to anti-CCP antibodies and anti-MCV antibodies in the diagnosis of rheumatoid arthritis. British Journal of Biomedical Science, 78(2), 67-71.

Ruiz-Villalba, A., Romero, J. P., Hernández, S. C., Vilas-Zornoza, A., Fortelny, N., Castro-Labrador, L., ... & Prósper, F. (2020). Single-cell RNA sequencing analysis reveals a crucial role for CTHRC1 (collagen triple helix repeat containing 1) cardiac fibroblasts after myocardial infarction. Circulation, 142(19), 1831-1847.

Wu, Q., Yang, Q., & Sun, H. (2018). Collagen triple helix repeat containing-1: A novel biomarker associated with disease activity in Systemic lupus erythematosus. Lupus, 27(13), 2076-2085.

Liu, Y., Abulimiti, N., & Wang, C. (2018). Collagen triple helix repeat containing 1 expression in osteosarcoma: a new predictor of prognosis. Annals of Clinical & Laboratory Science, 48(3), 338-344.

Liu, J., Li, W., Liu, S., Zheng, X., Shi, L., Zhang, W., & Yang, H. (2017). Knockdown of Collagen Triple Helix Repeat Containing 1 (CTHRC1) Inhibits Epithelial–Mesenchymal Transition and Cellular Migration in Glioblastoma Cells. Oncology research, 25(2), 225.

Guo, B., Yan, H., Li, L., Yin, K., Ji, F., & Zhang, S. (2017). Collagen triple helix repeat containing 1 (CTHRC1) activates Integrin β3/FAK signaling and promotes metastasis in ovarian cancer. Journal of ovarian research, 10(1), 1-13.

Wang, C., Li, Z., Shao, F., Yang, X., Feng, X., Shi, S., ... & He, J. (2017). High expression of Collagen Triple Helix Repeat Containing 1 (CTHRC1) facilitates progression of oesophageal squamous cell carcinoma through MAPK/MEK/ERK/FRA-1 activation. Journal of Experimental & Clinical Cancer Research, 36(1), 1-14.

Lai, Y. H., Chen, J., Wang, X. P., Wu, Y. Q., Peng, H. T., Lin, X. H., & Wang, W. J. (2017). Collagen triple helix repeat containing-1 negatively regulated by microRNA-30c promotes cell proliferation and metastasis and indicates poor prognosis in breast cancer. Journal of Experimental & Clinical Cancer Research, 36(1), 1-15.

Wu, Q., Yang, Q., & Sun, H. (2017). Role of collagen triple helix repeat containing-1 in tumor and inflammatory diseases. Journal of Cancer Research and Therapeutics, 13(4), 621.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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