Human Recombinant CTHRC1 protein, His Tag-1 (V2LY-0526-LY3411)

Name: Human Recombinant CTHRC1 protein, His Tag-1
SKU: V2LY-0526-LY3411
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant CTHRC1 protein, His Tag consist of Amino Acid: 1-243 and predicts a molecular mass of 24.5 kDa.

Molecule Mass

24.5 kDa

Verified

HPLC

Sequence

Amino Acid: 1-243

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

collagen triple helix repeat containing 1

Function

May act as a negative regulator of collagen matrix deposition.

Biological Process

Cell migration Source: Ensembl
Cochlea morphogenesis Source: Ensembl
Establishment of planar polarity involved in neural tube closure Source: Ensembl
Inner ear receptor cell stereocilium organization Source: Ensembl
Negative regulation of canonical Wnt signaling pathway Source: Ensembl
Ossification involved in bone remodeling Source: Ensembl
Positive regulation of osteoblast differentiation Source: Ensembl
Positive regulation of osteoblast proliferation Source: Ensembl
Positive regulation of protein binding Source: Ensembl
Wnt signaling pathway, planar cell polarity pathway Source: Ensembl

Cellular Location

Extracellular matrix

Involvement in disease

Barrett esophagus (BE):
A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes.

PTM

N-glycosylated.

Myngbay, A., Manarbek, L., Ludbrook, S., & Kunz, J. (2021). The role of collagen triple helix repeat-containing 1 protein (CTHRC1) in rheumatoid arthritis. International Journal of Molecular Sciences, 22(5), 2426.

Hu, T., Liu, Y., Tan, L., Huang, J., Yu, J., Wu, Y., ... & Xiang, Y. (2021). Value of serum collagen triple helix repeat containing-1 (CTHRC1) and 14-3-3η protein compared to anti-CCP antibodies and anti-MCV antibodies in the diagnosis of rheumatoid arthritis. British Journal of Biomedical Science, 78(2), 67-71.

Ruiz-Villalba, A., Romero, J. P., Hernández, S. C., Vilas-Zornoza, A., Fortelny, N., Castro-Labrador, L., ... & Prósper, F. (2020). Single-cell RNA sequencing analysis reveals a crucial role for CTHRC1 (collagen triple helix repeat containing 1) cardiac fibroblasts after myocardial infarction. Circulation, 142(19), 1831-1847.

Wu, Q., Yang, Q., & Sun, H. (2018). Collagen triple helix repeat containing-1: A novel biomarker associated with disease activity in Systemic lupus erythematosus. Lupus, 27(13), 2076-2085.

Liu, Y., Abulimiti, N., & Wang, C. (2018). Collagen triple helix repeat containing 1 expression in osteosarcoma: a new predictor of prognosis. Annals of Clinical & Laboratory Science, 48(3), 338-344.

Liu, J., Li, W., Liu, S., Zheng, X., Shi, L., Zhang, W., & Yang, H. (2017). Knockdown of Collagen Triple Helix Repeat Containing 1 (CTHRC1) Inhibits Epithelial–Mesenchymal Transition and Cellular Migration in Glioblastoma Cells. Oncology research, 25(2), 225.

Guo, B., Yan, H., Li, L., Yin, K., Ji, F., & Zhang, S. (2017). Collagen triple helix repeat containing 1 (CTHRC1) activates Integrin β3/FAK signaling and promotes metastasis in ovarian cancer. Journal of ovarian research, 10(1), 1-13.

Wang, C., Li, Z., Shao, F., Yang, X., Feng, X., Shi, S., ... & He, J. (2017). High expression of Collagen Triple Helix Repeat Containing 1 (CTHRC1) facilitates progression of oesophageal squamous cell carcinoma through MAPK/MEK/ERK/FRA-1 activation. Journal of Experimental & Clinical Cancer Research, 36(1), 1-14.

Lai, Y. H., Chen, J., Wang, X. P., Wu, Y. Q., Peng, H. T., Lin, X. H., & Wang, W. J. (2017). Collagen triple helix repeat containing-1 negatively regulated by microRNA-30c promotes cell proliferation and metastasis and indicates poor prognosis in breast cancer. Journal of Experimental & Clinical Cancer Research, 36(1), 1-15.

Wu, Q., Yang, Q., & Sun, H. (2017). Role of collagen triple helix repeat containing-1 in tumor and inflammatory diseases. Journal of Cancer Research and Therapeutics, 13(4), 621.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant CTHRC1 protein, His Tag (CAT#: V2LY-0526-LY1477)

Human Recombinant CTHRC1 protein, hFc Tag (CAT#: V2LY-0526-LY3408)

Human Recombinant CTHRC1 protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY3409)

Human Recombinant CTHRC1 protein, His Tag (CAT#: V2LY-0526-LY3410)

Mouse Recombinant CTHRC1 protein, His Tag (CAT#: V2LY-0526-LY8169)

Rat Recombinant CTHRC1 protein, His Tag (CAT#: V2LY-0526-LY9312)

Mouse Cthrc1 ELISA Kit (CAT#: V2LY-0626-LY2206)

Human CTHRC1 ELISA Kit (CAT#: V2LY-0626-LY4421)

Human CTHRC1 ELISA Kit (2) (CAT#: V2LY-0626-LY5671)

Related Products

Human Recombinant CTHRC1 protein, His Tag (CAT#: V2LY-0526-LY3410)

Rat Recombinant CTHRC1 protein, His Tag (CAT#: V2LY-0526-LY9312)

Human Recombinant CTHRC1 protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY3409)

Rabbit Anti-CTHRC1 Recombinant Antibody (62) (CAT#: V2LY-0125-LY266)

Human Recombinant CTHRC1 protein, hFc Tag (CAT#: V2LY-0526-LY3408)

Cynomolgus Recombinant CTHRC1 protein, His Tag (CAT#: V2LY-0526-LY1477)

Rabbit Anti-CTHRC1 Recombinant Antibody (CBFYC-2388) (CAT#: V2LY-0125-LY269)

Mouse Anti-CTHRC1 Recombinant Antibody (C4141) (CAT#: V2LY-0125-LY265)

Mouse Recombinant CTHRC1 protein, His Tag (CAT#: V2LY-0526-LY8169)

Mouse Anti-CTHRC1 Recombinant Antibody (CBFYC-2386) (CAT#: V2LY-0125-LY267)

Isotype control

For research use only. Not intended for any clinical use.

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