Mouse Cthrc1 ELISA Kit (V2LY-0626-LY2206)

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Tested Data
Datasheet
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Basic Information

Sensitivity
0.28 ng/mL
Detection Range
0.5-200 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Mouse
Assay Type
Sandwich
Reactivity
Mouse
Assay Time
1.5 h
Molecule Mass
26.5 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
collagen triple helix repeat containing 1
Function
May act as a negative regulator of collagen matrix deposition.
Biological Process
Cell migration Source: Ensembl
Cochlea morphogenesis Source: Ensembl
Establishment of planar polarity involved in neural tube closure Source: Ensembl
Inner ear receptor cell stereocilium organization Source: Ensembl
Negative regulation of canonical Wnt signaling pathway Source: Ensembl
Ossification involved in bone remodeling Source: Ensembl
Positive regulation of osteoblast differentiation Source: Ensembl
Positive regulation of osteoblast proliferation Source: Ensembl
Positive regulation of protein binding Source: Ensembl
Wnt signaling pathway, planar cell polarity pathway Source: Ensembl
Cellular Location
Extracellular matrix
Involvement in disease
Barrett esophagus (BE):
A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes.
PTM
N-glycosylated.

Myngbay, A., Manarbek, L., Ludbrook, S., & Kunz, J. (2021). The role of collagen triple helix repeat-containing 1 protein (CTHRC1) in rheumatoid arthritis. International Journal of Molecular Sciences, 22(5), 2426.

Hu, T., Liu, Y., Tan, L., Huang, J., Yu, J., Wu, Y., ... & Xiang, Y. (2021). Value of serum collagen triple helix repeat containing-1 (CTHRC1) and 14-3-3η protein compared to anti-CCP antibodies and anti-MCV antibodies in the diagnosis of rheumatoid arthritis. British Journal of Biomedical Science, 78(2), 67-71.

Ruiz-Villalba, A., Romero, J. P., Hernández, S. C., Vilas-Zornoza, A., Fortelny, N., Castro-Labrador, L., ... & Prósper, F. (2020). Single-cell RNA sequencing analysis reveals a crucial role for CTHRC1 (collagen triple helix repeat containing 1) cardiac fibroblasts after myocardial infarction. Circulation, 142(19), 1831-1847.

Wu, Q., Yang, Q., & Sun, H. (2018). Collagen triple helix repeat containing-1: A novel biomarker associated with disease activity in Systemic lupus erythematosus. Lupus, 27(13), 2076-2085.

Liu, Y., Abulimiti, N., & Wang, C. (2018). Collagen triple helix repeat containing 1 expression in osteosarcoma: a new predictor of prognosis. Annals of Clinical & Laboratory Science, 48(3), 338-344.

Liu, J., Li, W., Liu, S., Zheng, X., Shi, L., Zhang, W., & Yang, H. (2017). Knockdown of Collagen Triple Helix Repeat Containing 1 (CTHRC1) Inhibits Epithelial–Mesenchymal Transition and Cellular Migration in Glioblastoma Cells. Oncology research, 25(2), 225.

Guo, B., Yan, H., Li, L., Yin, K., Ji, F., & Zhang, S. (2017). Collagen triple helix repeat containing 1 (CTHRC1) activates Integrin β3/FAK signaling and promotes metastasis in ovarian cancer. Journal of ovarian research, 10(1), 1-13.

Wang, C., Li, Z., Shao, F., Yang, X., Feng, X., Shi, S., ... & He, J. (2017). High expression of Collagen Triple Helix Repeat Containing 1 (CTHRC1) facilitates progression of oesophageal squamous cell carcinoma through MAPK/MEK/ERK/FRA-1 activation. Journal of Experimental & Clinical Cancer Research, 36(1), 1-14.

Lai, Y. H., Chen, J., Wang, X. P., Wu, Y. Q., Peng, H. T., Lin, X. H., & Wang, W. J. (2017). Collagen triple helix repeat containing-1 negatively regulated by microRNA-30c promotes cell proliferation and metastasis and indicates poor prognosis in breast cancer. Journal of Experimental & Clinical Cancer Research, 36(1), 1-15.

Wu, Q., Yang, Q., & Sun, H. (2017). Role of collagen triple helix repeat containing-1 in tumor and inflammatory diseases. Journal of Cancer Research and Therapeutics, 13(4), 621.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant CTHRC1 protein, His Tag (CAT#: V2LY-0526-LY1477)

Human Recombinant CTHRC1 protein, hFc Tag (CAT#: V2LY-0526-LY3408)

Human Recombinant CTHRC1 protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY3409)

Human Recombinant CTHRC1 protein, His Tag (CAT#: V2LY-0526-LY3410)

Human Recombinant CTHRC1 protein, His Tag-1 (CAT#: V2LY-0526-LY3411)

Mouse Recombinant CTHRC1 protein, His Tag (CAT#: V2LY-0526-LY8169)

Rat Recombinant CTHRC1 protein, His Tag (CAT#: V2LY-0526-LY9312)

Human CTHRC1 ELISA Kit (CAT#: V2LY-0626-LY4421)

Human CTHRC1 ELISA Kit (2) (CAT#: V2LY-0626-LY5671)

Related Products

Rabbit Anti-CTHRC1 Recombinant Antibody (062) (CAT#: V2LY-0125-LY263)

Rat Recombinant CTHRC1 protein, His Tag (CAT#: V2LY-0526-LY9312)

Human Recombinant CTHRC1 protein, hFc Tag (CAT#: V2LY-0526-LY3408)

Mouse Anti-CTHRC1 Recombinant Antibody (C4141) (CAT#: V2LY-0125-LY265)

Human Recombinant CTHRC1 protein, His Tag-1 (CAT#: V2LY-0526-LY3411)

Human Recombinant CTHRC1 protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY3409)

Rabbit Anti-CTHRC1 Recombinant Antibody (62) (CAT#: V2LY-0125-LY266)

Cynomolgus Recombinant CTHRC1 protein, His Tag (CAT#: V2LY-0526-LY1477)

Rabbit Anti-CTHRC1 Recombinant Antibody (CBFYC-2388) (CAT#: V2LY-0125-LY269)

Human CTHRC1 ELISA Kit (CAT#: V2LY-0626-LY4421)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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