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Mouse Anti-CTNNBIP1 Recombinant Antibody (3B3) (CBMAB-A1984-LY)

The product is antibody recognizes CTNNBIP1. The antibody 3B3 immunoassay techniques such as: WB, ELISA.
See all CTNNBIP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3B3
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
CTNNBIP1 (NP_064633, 1 a.a. ~ 81 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
catenin, beta interacting protein 1
Introduction
The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
Entrez Gene ID
56998
UniProt ID
Q9NSA3
Alternative Names
ICAT; MGC15093
Function
Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway.
Biological Process
Anterior/posterior pattern specification Source: Ensembl
Branching involved in ureteric bud morphogenesis Source: Ensembl
Negative regulation of DNA binding Source: Ensembl
Negative regulation of DNA-binding transcription factor activity Source: BHF-UCL
Negative regulation of mesenchymal cell proliferation Source: BHF-UCL
Negative regulation of protein binding Source: BHF-UCL
Negative regulation of protein-containing complex assembly Source: Ensembl
Negative regulation of smooth muscle cell proliferation Source: Ensembl
Negative regulation of transcription initiation from RNA polymerase II promoter Source: Ensembl
Negative regulation of Wnt signaling pathway Source: GO_Central
Positive regulation of monocyte differentiation Source: BHF-UCL
Positive regulation of osteoblast differentiation Source: BHF-UCL
Regulation of vascular permeability involved in acute inflammatory response Source: BHF-UCL
Wnt signaling pathway Source: UniProtKB-KW
Cellular Location
Cytoplasm; Nucleus

Liu, S., Liu, D., Liu, J., Liu, J., & Zhong, M. (2021). miR‐29a‐3p promotes migration and invasion in ameloblastoma via Wnt/β‐catenin signaling by targeting catenin beta interacting protein 1. Head & Neck, 43(12), 3911-3921.

Wang, C., Wang, H., Peng, Y., Zeng, B., Zhang, Y., Tang, X., ... & Yang, Z. (2021). CTNNBIP1 modulates keratinocyte proliferation through promoting the transcription of β‐catenin/TCF complex downstream genes. Journal of the European Academy of Dermatology and Venereology, 35(2), 368-379.

Zhang, Z., Jiang, W., Hu, M., Gao, R., & Zhou, X. (2021). MiR-486–3p promotes osteogenic differentiation of BMSC by targeting CTNNBIP1 and activating the Wnt/β-catenin pathway. Biochemical and Biophysical Research Communications, 566, 59-66.

Kosari‐Monfared, M., Nikbakhsh, N., Fattahi, S., Ghadami, E., Ranaei, M., Taheri, H., ... & Akhavan‐Niaki, H. (2019). CTNNBIP1 downregulation is associated with tumor grade and viral infections in gastric adenocarcinoma. Journal of cellular physiology, 234(3), 2895-2904.

Chang, J. M., Tsai, A. C. D., Huang, W. R., & Tseng, R. C. (2019). The alteration of CTNNBIP1 in lung cancer. International journal of molecular sciences, 20(22), 5684.

Bi, W., Huang, J., Nie, C., Liu, B., He, G., Han, J., ... & Zhang, J. (2018). CircRNA circRNA_102171 promotes papillary thyroid cancer progression through modulating CTNNBIP1-dependent activation of β-catenin pathway. Journal of Experimental & Clinical Cancer Research, 37(1), 1-9.

Fu, X., Zhu, X., Qin, F., Zhang, Y., Lin, J., Ding, Y., ... & Gao, Q. (2018). Linc00210 drives Wnt/β-catenin signaling activation and liver tumor progression through CTNNBIP1-dependent manner. Molecular cancer, 17(1), 1-14.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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