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Mouse Anti-CTNND1 Recombinant Antibody (15D2) (CBMAB-D0123-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Catenin Delta 1 (CTNND1). The antibody can be used for immunoassay techniques, such as ELISA, ICC, IF, IP, WB.
See all CTNND1 antibodies
Published Data
Fig.1 Caco2 cells were grown to polarize and subjected to immunofluorescence for p120 and the core proteins of PABPC1.
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Fig.2 Western blots of PLEKHA7, p120 of Caco2 cells for the same markers.
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Fig.3 WT primary mKer immuno­stained for CLASP2 and p120 in the presence of calcium to induce formation of AJs.
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Fig.4 CLASP2 was immunoprecipitated from mKer treated with calcium, and the immunoprecipitates (IP) were analyzed for CLASP2, ECad, and p120 by immunoblotting.
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Summary

Host Animal
Mouse
Specificity
Human, Dog, Mouse, Rat
Clone
15D2
Antibody Isotype
IgG1, κ
Application
ELISA, ICC, IF, IP, WB

Basic Information

Immunogen
Recombinant fusion protein derived from the C-terminus of murine p120ct
Specificity
Human, Dog, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Catenin Delta 1
Introduction
CTNND1 (Catenin Delta 1) is a protein coding gene. Diseases associated with CTNND1 include Blepharocheilodontic Syndrome 2 and Blepharocheilodontic Syndrome 1. Among its related pathways are N-cadherin signaling events and PAK Pathway.
Entrez Gene ID
Human1500
Mouse12388
Rat311163
Dog483489
UniProt ID
HumanO60716
MouseP30999
RatD3ZZZ9
DogE2R434
Alternative Names
Catenin Delta 1; Catenin (Cadherin-Associated Protein), Delta 1; Cadherin-Associated Src Substrate; P120 Catenin; P120(CAS); P120(CTN); CAS; Catenin Delta-1;
Function
Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349).

Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349).

Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476).
Biological Process
Adherens junction organization Source: Reactome
Brain development Source: Ensembl
Cell-cell adhesion Source: GO_Central
Cell-cell adhesion mediated by cadherin Source: UniProtKB
Cell-cell junction assembly Source: GO_Central
Entry of bacterium into host cell Source: Reactome
Negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
Protein stabilization Source: UniProtKB
Regulation of postsynaptic membrane neurotransmitter receptor levels Source: SynGO
Wnt signaling pathway Source: UniProtKB-KW
Cellular Location
Nucleus; Cell membrane; Cytoplasm; Adherens junction. Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts (PubMed:15240885, PubMed:17047063). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm (PubMed:17047063). CDH1 enhances cell membrane localization (PubMed:15240885). Isoforms 4A and 1AB are excluded from the nucleus (PubMed:11896187).
Isoform 1A&2A&3A: Nucleus
Involvement in disease
Blepharocheilodontic syndrome 2 (BCDS2):
A form of blepharocheilodontic syndrome, a rare autosomal dominant disorder. It is characterized by lower eyelid ectropion, upper eyelid distichiasis, euryblepharon, bilateral cleft lip and palate, and features of ectodermal dysplasia, including hair anomalies, conical teeth and tooth agenesis. An additional rare manifestation is imperforate anus. There is considerable phenotypic variability among affected individuals.
PTM
Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK5. Dephosphorylated by PTPRJ.

Liu, Y., Yuan, H., & He, T. (2022). Downregulated circular RNA hsa_circ_0005797 inhibits endometrial cancer by modulating microRNA-298/Catenin delta 1 signaling. Bioengineered, 13(3), 4634-4645.

Wei, D., Tian, M., Fan, W., Zhong, X., Wang, S., Chen, Y., & Zhang, S. (2021). Circular RNA circ_0000043 promotes endometrial carcinoma progression by regulating miR-1271-5p/CTNND1 axis. Archives of Gynecology and Obstetrics, 303(4), 1075-1087.

Gao, X. H., Zhang, Y. L., Zhang, Z. Y., Guo, S. S., Chen, X. B., & Guo, Y. Z. (2020). MicroRNA-96-5p represses breast cancer proliferation and invasion through Wnt/β-catenin signaling via targeting CTNND1. Scientific Reports, 10(1), 1-9.

Liu, D., Zhang, H., Cui, M., Chen, C., & Feng, Y. (2020). Hsa-miR-425-5p promotes tumor growth and metastasis by activating the CTNND1-mediated β-catenin pathway and EMT in colorectal cancer. Cell Cycle, 19(15), 1917-1927.

Yu, X., Sheng, P., Sun, J., Zhao, X., Zhang, J., Li, Y., ... & Jiang, H. (2020). The circular RNA circMAST1 promotes hepatocellular carcinoma cell proliferation and migration by sponging miR-1299 and regulating CTNND1 expression. Cell death & disease, 11(5), 1-16.

Han, L., Li, Z., Jiang, Y., Jiang, Z., & Tang, L. (2019). SNHG29 regulates miR-223-3p/CTNND1 axis to promote glioblastoma progression via Wnt/β-catenin signaling pathway. Cancer cell international, 19(1), 1-11.

Shen, Q., He, T., & Yuan, H. (2019). Hsa_circ_0002577 promotes endometrial carcinoma progression via regulating miR-197/CTNND1 axis and activating Wnt/β-catenin pathway. Cell Cycle, 18(11), 1229-1240.

Cao, N., Mu, L., Yang, W., Liu, L., Liang, L., & Zhang, H. (2018). MicroRNA-298 represses hepatocellular carcinoma progression by inhibiting CTNND1-mediated Wnt/β-catenin signaling. Biomedicine & Pharmacotherapy, 106, 483-490.

Kievit, A., Tessadori, F., Douben, H., Jordens, I., Maurice, M., Hoogeboom, J., ... & van Haaften, G. (2018). Variants in members of the cadherin–catenin complex, CDH1 and CTNND1, cause blepharocheilodontic syndrome. European Journal of Human Genetics, 26(2), 210-219.

Liao, X. H., Zhang, Y., Dong, W. J., Shao, Z. M., & Li, D. Q. (2017). Chromatin remodeling protein MORC2 promotes breast cancer invasion and metastasis through a PRD domain-mediated interaction with CTNND1. Oncotarget, 8(58), 97941.

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For research use only. Not intended for any clinical use.

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