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Rabbit Anti-CTNND2 Monoclonal Antibody (EPR17628) (CBMAB-1009-YC)

Provided herein is a rabbit monoclonal antibody against Mouse CTNND2. The antibody, clone EPR17628, can be used for immunoassay techniques, such as ICC, IF and WB.
See all CTNND2 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat
Clone
EPR17628
Antibody Isotype
IgG
Application
ICC, IF, WB

Basic Information

Immunogen
Synthetic peptide within Mouse delta 2 Catenin aa 1-100.
Specificity
Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
Introduction
Catenin delta 2 (CTNND2) is an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. CTNND2 promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. CTNND2 is associated with decreased expression of tumor suppressor E-cadherin in this tissue.
Entrez Gene ID
Mouse18163
Rat114028
UniProt ID
MouseO35927
RatO35116
Alternative Names
GT24; NPRAP
Function
Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484).

Involved in the regulation of Wnt signaling (PubMed:25807484).

It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity).

Functions as a transcriptional activator when bound to ZBTB33 (By similarity).

May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules.
Biological Process
Cell adhesion Source: ProtInc
Cell-cell adhesion Source: GO_Central
Cell-cell junction assembly Source: GO_Central
Dendritic spine morphogenesis Source: UniProtKB
Regulation of canonical Wnt signaling pathway Source: UniProtKB
Signal transduction Source: ProtInc
Synapse organization Source: UniProtKB
Wnt signaling pathway Source: UniProtKB-KW
Cellular Location
Nucleus; Adherens junction; Dendrite; Perikaryon
Involvement in disease
Defects in CTNND2, including deleterious missense and copy number variants (CNVs) are involved in autism, a complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation.
PTM
O-glycosylated.
Phosphorylated by CDK5 (By similarity). Phosphorylated by GSK3B (PubMed:19706605).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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