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Mouse Anti-CTRC Recombinant Antibody (40) (CBMAB-C0589-YY)

This product is mouse antibody that recognizes CTRC. The antibody 40 can be used for immunoassay techniques such as: WB, ELISA, IHC-P, IHC-Fr, IF
See all CTRC antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
40
Antibody Isotype
IgG3
Application
WB, ELISA, IHC-P, IHC-Fr, IF

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG3
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein A purified
Buffer
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Chymotrypsin C
Entrez Gene ID
Human11330
Mouse76701
Rat362653
UniProt ID
HumanQ99895
MouseQ3SYP2
RatP55091
Function
Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity.
Biological Process
Cellular calcium ion homeostasis Source: MGI
Cobalamin metabolic process Source: Reactome
Proteolysis Source: MGI
Cellular Location
Extracellular region
Involvement in disease
Pancreatitis, hereditary (PCTT):
Disease susceptibility is associated with variants affecting the gene represented in this entry. Loss-of-function CTRC variants predispose to pancreatitis by diminishing its protective trypsin-degrading activity (PubMed:18059268). They cause loss of function by one or more of three mechanisms: reduced secretion, catalytic defect and increased degradation by trypsin (PubMed:22942235).
A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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